JAMA Otolaryngology Head and Neck Surgery 2024-09-01

JAMA Otolaryngology–Head & Neck Surgery

Publication date 01-09-2024


Mission Statement: JAMA Otolaryngology–Head & Neck Surgery provides timely information for physicians and scientists concerned with diseases of the head and neck. Given the diversity of structure and function based in this anatomic region, JAMA Otolaryngology–Head & Neck Surgery publishes clinical, translational, and population health research from an array of disciplines. We place a high priority on strong study designs that accurately identify etiologies, evaluate diagnostic strategies, and distinguish among treatment options and outcomes. Our objectives are to (1) publish original contributions that will enhance the clinician’s understanding of otolaryngologic disorders, benefit the care of our patients, and stimulate research in our field; (2) forecast important advances within otolaryngology–head and neck surgery, particularly as they relate to the prevention, diagnosis, and treatment of disease through clinical and translational research, including that of the human genome and novel imaging techniques; (3) address questions of clinical outcomes and cost-effectiveness that result from clinical intervention, which grow in importance as health care providers are increasingly challenged to provide evidence of enhanced survival and quality of life; (4) provide expert reviews of topics that keep our readers current with true advances and also to provide a valuable educational resource for trainees in the several disciplines that treat patients with diseases of the head and neck; (5) serve as a forum for the concerns of otolaryngologists, such as socioeconomic, legal, ethical, and medical issues; (6) provide helpful critiques that enable contributing authors to improve their submissions. We encourage a concise presentation of information and employ an abstract format that efficiently assesses validity and relevance from a clinical perspective. This approach promotes succinct yet complete presentation for our readers and electronic information resources. We believe this approach typifies the commitment of JAMA Otolaryngology–Head & Neck Surgery to providing important information that is easily interpreted by its diverse readership.

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Financial Burden of Dental Care Among Patients With Head and Neck Cancer

B Ben Dor,A Villa,C Hayes,E Alpert,DS Shepard,ST Sonis

Publication date 01-09-2024


This survey study examines oral and dental complications of cancer treatment among patients with head and neck cancer, the association of cancer treatment with dental care use, and costs of associated dental treatment.

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Predictors of Response to Cognitive Behavioral Therapy in Patients With Tinnitus

L Mueller,D Kallogjeri,MR Frumkin,K Dizdar,J Shin,T Rodebaugh,JF Piccirillo

Publication date 01-09-2024


This secondary cohort analysis identifies clinical predictors of patient response to cognitive behavioral therapy for the treatment of tinnitus.

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Cutaneous Sinus at Sternoclavicular Joint

XQ Huang,JL Zheng,YM Fan

Publication date 01-09-2024


A 32-year-old female patient presented with chronic discharging sinus with recurrent infection at the left sternoclavicular joint. What is your diagnosis?

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Editorial Fellowship—Call for Applicants

JF Piccirillo

Publication date 01-09-2024


Introducing the JAMA Otolaryngology–Head & Neck Surgery Editorial Fellowship, a 2-year program designed for otolaryngologists. This immersive fellowship provides early-career faculty with the opportunity to join a dedicated editorial team focused on advancing the field of otolaryngology–head and neck surgery. Our goal is to educate otolaryngologists and foster future leaders in the specialty, making this fellowship a crucial part of our commitment.

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Exogenous Estrogen and Head and Neck Cancer

WC Lin,ES Chang,JC Wei

Publication date 01-09-2024


To the Editor We read with great interest the article by Doll et al regarding exogenous estrogen in the development of head and neck cancers. We appreciated the results of this cohort study that head and neck cancer prevalence may be higher in female patients taking oral contraceptives and lower in female patients taking hormone replacement therapy. However, we want to highlight some of our concerns.

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Exogenous Estrogen and Head and Neck Cancer

TN Yang,C Shih,YS Kao

Publication date 01-09-2024


To the Editor We read with great interest the article from Doll et al. This study showed that oral contraceptives (OCs) are associated with increased risk of head and neck cancer (HNC), while hormone replacement therapy (HRT) was associated with decreased risk of HNC. To further elucidate the findings and enhance the robustness of the conclusions, we would like to propose several recommendations for consideration.

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Concerns Regarding Hearing Loss and Cognitive Outcomes

H Wang,Y Li,C Wang

Publication date 01-09-2024


To the Editor In a recent article, Stickel et al contributed to exploring the association of hearing loss with 7-year cognitive change and mild cognitive impairment risk among 6113 Hispanic and Latino adults using a large community cohort. The findings suggest that hearing loss is associated with decreased cognitive performance 7 years later and increased change (slowing) in processing speed. However, we have 2 concerns about this article.

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Exogenous Estrogen and Head and Neck Cancer—Reply

C Doll,E Hofmann,S Preissner

Publication date 01-09-2024


In Reply We are pleased with the ongoing scientific discussion on the role of oral contraceptives (OCs) and hormone replacement therapy (HRT) in the development of head and neck cancer (HNC). We have read with great interest 2 Letters to the Editor by Lin et al and Yang et al and would like to address the concerns raised.

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Concerns Regarding Hearing Loss and Cognitive Outcomes—Reply

AM Stickel,W Tarraf,HM González

Publication date 01-09-2024


In Reply Wang and colleagues noted some concerns regarding our recent publication on the associations between hearing loss and 7-year cognitive outcomes among Hispanic/Latino adults enrolled in the Study of Latinos—Investigation of Neurocognitive Aging, an ancillary study to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). We appreciate the discourse and wish to speak to some of these concerns.

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Comparing Self-Fitting Strategies for Over-the-Counter Hearing Aids

M Knoetze,V Manchaiah,K De Sousa,DR Moore,W Swanepoel

Publication date 01-09-2024


This pseudorandomized clinical trial examines Abbreviated Profile of Hearing Aid Benefit scores for self-adjustment vs in situ audiometric fitting strategies for over-the -counter hearing aids among adults with hearing loss.

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Voice Disorder Prevalence and Vocal Health Characteristics in Adolescents

RB Fujiki,SL Thibeault

Publication date 01-09-2024


This survey study examines the prevalence of adolescent voice problems in the US and the symptoms, voice use patterns, and risk factors associated with these problems.

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Odynodysphagia and Oropharyngeal Mass

E Al Hakim,F Vachin,F Carsuzaa

Publication date 01-09-2024


A 60-year-old female patient presented with odynophagia and dysphagia and was found to have left-sided erythematous oropharyngeal bulging. What is your diagnosis?

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Errors in Figure 2

Publication date 01-09-2024


In the Original Investigation titled “Extent of Surgery for Medullary Thyroid Cancer and Prevalence of Occult Contralateral Foci,” published online on January 25, 2024, and in the March 2024 print issue, there were errors in Figure 2. “9 Presence of contralateral nodule” and “56 Presence of contralateral nodule” should be “9 Absence of contralateral nodule” and “56 Absence of contralateral nodule,” respectively. This article was corrected online.

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Differentiating Superior and Inferior Parathyroid Adenomas

PM Bunch,RW Randle

Publication date 01-09-2024


In their diagnostic study including 426 patients with primary hyperparathyroidism, Hannabass et al describe and evaluate a novel ultrasonography-based technique for predicting parathyroid adenoma gland origin (ie, superior vs inferior). Specifically, the proposed approach uses the cranial angle formed between the adenoma’s long axis and the strap musculature as measured in the longitudinal orientation to inform the likely gland origin. An obtuse cranial angle (ie, >90°) supports a superior gland origin, an acute angle (ie, <90°) supports an inferior gland origin, and the angle is considered not definable if the long axis of the parathyroid adenoma parallels the strap musculature (ie, approximates 180°) or the parathyroid adenoma appears round in the longitudinal orientation without an identifiable long axis. Among parathyroid adenomas with a definable cranial angle, the authors found their proposed approach to be 72.9% accurate for determining superior vs inferior gland origin using operative findings as the criterion standard. The promising results from this study warrant prospective validation and potential incorporation into clinical practice, where the cranial angle assessment would be expected to add negligible scanning time to future ultrasonography examinations and could likely be determined retrospectively in practices where still images or cine clips are routinely obtained in the longitudinal orientation. However, it is important to recognize that a substantial proportion (29.0%) of adenomas had no definable cranial angle, such that the proposed method is best considered complementary to, rather than a replacement for, existing imaging-based methods for predicting superior vs inferior parathyroid gland origin.

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Cutaneous Squamous Cell Carcinoma is a Different Diagnosis From Head and Neck Squamous Cell Carcinoma

ES Ruiz,AW Silk,RK Sethi

Publication date 01-09-2024


To the Editor In their Observation, Corbett et al presents a patient with metastatic cutaneous squamous cell carcinoma (cSCC) to lymph nodes who received 2 doses of pembrolizumab and had a complete clinical and radiologic response. This report is not novel based on evidence to date. The National Comprehensive Cancer Network includes neoadjuvant cemiplimab as an option for select patients with advanced resectable cSCCs.

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All or Nothing in Surgical Treatment of Precancerous Oral Cavity Lesions

G Licci,O Gallo

Publication date 01-09-2024


To the Editor We read with great interest the article by Cooper et al. The study revealed that 28.0% of patients diagnosed with biopsy-proven oral cavity carcinoma in situ exhibited occult invasive disease on definitive resection. Although most of these patients have a high survival rate due to a low disease T stage, the patients who underwent surgical resection experienced significantly superior survival outcomes compared with their nonsurgical counterparts. This underscores the importance of considering this type of treatment over others.

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Langerhans Cell Histiocytosis of the Nasal Mucosa

A Narayanan,F Rosado,A Vaughn,M Ryan

Publication date 01-09-2024


This case report describes a female patient in her early 40s with left-sided cervical lymphadenopathy, facial swelling, nasal congestion, and a left nasal mass.

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Cutaneous Squamous Cell Carcinoma is a Different Diagnosis From Head and Neck Squamous Cell Carcinoma—Reply

M Corbett,R Ramli,F O'Duffy

Publication date 01-09-2024


In Reply Many thanks to Ruiz et al for their correspondence. Several interesting points are raised in this response.

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All or Nothing in Surgical Treatment of Precancerous Oral Cavity Lesions—Reply

DJ Cooper,BA Miles,WJ Talcott

Publication date 01-09-2024


In Reply We thank Licci and Gallo for their insights regarding our study that assessed presence of occult invasive disease in biopsy-proven oral cavity carcinoma in situ on definitive resection. Our primary objective was to characterize the rate of occult invasive disease in these lesions and secondarily to identify factors associated with increased risk of invasive disease. We also sought to compare clinical outcomes in patients who proceeded with surgical resection vs no surgery, although we recognize the limitations of this retrospective population-based cohort analysis. Indeed, our study relies on pathology data from an initial incisional biopsy approach to accomplish all 3 of these aims.

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Parathyroid Adenoma Orientation for Gland Embryologic Origin on Ultrasonography

KR Hannabass,J Austerlitz,JE Noel,LA Orloff

Publication date 01-09-2024


This diagnostic study aims to determine if the association between the long axis of a parathyroid adenoma candidate and strap musculature on sagittal ultrasonography can be used to predict the embryologic origin of the gland.

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Intraoperative Pathology Consultation in Unknown Primary Squamous Cell Carcinoma

DR Awad,A Konanur,RL Ferris,S Kim,U Duvvuri,SI Chiosea

Publication date 01-09-2024


This case series study assesses the sensitivity, specificity, and predictive values of primary tumor localization through intraoperative pathology consultation during transoral robotic surgery for human papillomavirus–associated squamous cell carcinoma for unknown primary tumors.

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Long-Term Outcomes of Self-Fit vs Audiologist-Fit Hearing Aids

KC De Sousa,V Manchaiah,DR Moore,MA Graham,W Swanepoel

Publication date 01-09-2024


This comparative effectiveness research study compares long-term audiologist-fit hearing aid outcomes and self-fit hearing aid outcomes according to participants’ self-reported measures.

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Olfactory Impairment and Frailty

BSY Yeo,JH Chan,BKJ Tan,X Liu,L Tay,NWY Teo,TC Charn

Publication date 01-09-2024


This systematic review and meta-analysis examines the association between olfactory impairment and frailty.

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