Gözde Bayramoglu Cabuk Adnan Fuat Buyuklu Recep Karamert Songül Aksoy a Department of Audiology, Faculty of Medicine, Gazi University, Ankara, Turkeyb Department of Otorhinolaryngology and Head Neck Surgery, Faculty of Medicine, Baskent University, Ankara, Turkeyc Department of Otorhinolaryngology and Head Neck Surgery, Faculty of Medicine, Gazi University, Ankara, Turkeyd Department of Audiology, Faculty of Health Sciences, Lokman Hekim University, Ankara, Turkey
Publication date 10-06-2024
To ensure that subjective tinnitus patients develop positive attitudes toward tele-audiology. This study investigates the appropriateness of the internet-based software in patients with subjective tinnitus. Patients between the ages of 19 and 59 applying to the clinic with the subjective tinnitus filled in Tinnitus Handicap Index (THI) and Coronavirus Anxiety Scale (CAS). Visual Numeric Scale (VNS) was applied to the patients to complaint of tinnitus. Parameter measurements related to hearing and tinnitus were performed clinically. After the evaluations, 54 participants were divided into two groups to receive the 'Basic Information Material Service' (BIMS) face-to-face and online. Afterwards, THI and VNS were used to determine the current status. There was no significant difference between the groups that received BIMS with 2 different methods ( Online intervention is as effective as face-to-face interaction in the management of tinnitus.
Pubmed PDF WebMaki Inoue Mariko Hirama Noboru Ogahara Masahiro Takahashi Nobuhiko Oridate a Department of Otorhinolaryngology, Kanagawa Children‘s Medical Center, Yokohama, Japanb Department of Otorhinolaryngology, Minamikase E.N.T. Clinic, Kawasaki, Japanc Department of Otorhinolaryngology, Yokohama Medical and Welfare Center Konan, Yokohama, Japand Department of Otorhinolaryngology, International University of Health and Welfare, Mita Hospital, Tokyo, Japane Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University Hospital, Yokohama, Japan
Publication date 12-06-2024
Factors related to surgical outcomes of type I tympanoplasty for tympanic membrane (TM) perforation in children are controversial. To investigate factors related to anatomical results of type I tympanoplasty for TM perforation 1 year after surgery. We examined 68 ears. Anatomical results were determined based on the presence or absence of re-perforation, atelectasis, and otitis media with effusion. We retrospectively analyzed factors based on age (≤8 and >8 years), cause and size of TM perforation (<50% and ≥50%), history of asthma and cleft palate, and size of mastoid air cell system in bilateral ears before tympanoplasty. Audiological prognosis was evaluated in ears with anatomical success 1 year after surgery. Anatomical success was achieved in 80.9% (55/68) of the ears. No significant differences were observed between these factors and anatomical results. All children with cleft palate had anatomical success. Mean pure-tone average (0.5-4 k Hz) was 16.25 dB HL for ears with both TM perforations <50% and ≥50%. We observed no significant relationship between factors considered and surgical outcomes. However, audiological prognosis was favorable for anatomical success regardless of TM perforation size. Accordingly, type I tympanoplasty is considered useful for TM perforation in children.
Pubmed PDF WebKun Du Zhihui Pang Hongfei Lou Hongmeng Yu a Department of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, PR Chinab Research Units of New Technologies of Endoscopic Surgery in Skull Base Tumor (2018RU003), Chinese Academy of Medical Sciences, Beijing, Chinac Research Unit of Diagnosis and Treatment of Chronic Nasal Disease, Chinese Academy of Medical Sciences, Beijing, China
Publication date 16-07-2024
Presently, the impact of Chronic rhinosinusitis with nasal polyps (CRSwNP) on asthma onset is unknown. To evaluate the role of CRSwNP in asthma onset. A total of 3107 CRSwNP patients were retrospectively screened from 1 January 2018, to 31 May 2021; 624 patients were enrolled. Clinical data regarding nasal symptoms, Lund-Mackay scores, blood eosinophil percentage, and onset of asthma were analyzed. Patients were divided into different groups according to past history of nasal polyps, Lund-Mackay score, and the extent of blood eosinophilia. Asthma-free rates between these subgroups were analyzed by Kaplan-Meier curves and Cox regression models. The prevalence of asthma was 10.90% in patients with CRSwNP, and new-onset asthma occurred in 3.14% of these patients. Higher Lund-Mackay scores for ethmoid sinus and maxillary sinus (E/M) and blood eosinophil percentages were two independent risk factors for new-onset asthma, with hazard ratios of 1.267 (95%CI, 1.155-1.390) and 1.224 (95%CI, 1.054-1.422), respectively. CRSwNP patients with an E/M ratio > 2.33 or a blood Eos percentage > 5.5% were at risk for asthma onset. Blood eosinophilia and a higher E/M score ratio were associated with new-onset asthma in patients with CRSwNP.
Pubmed PDF WebTianye Yang Jun Liu a Department of Otorhinolaryngology, Zhejiang Chinese Medical University First Clinical School of Medicine, Hangzhou, Zhejiang Province, People’s Republic of Chinab Department of Otorhinolaryngology, Zhejiang Provincial Hospital of Chinese Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, People’s Republic of China
Publication date 26-06-2024
The outcome of clinical treatment for idiopathic sudden sensorineural hearing loss (ISSNHL) is frequently the primary concern. For the convenient prediction of reference prognosis outcomes in patients with ISSNHL. Patients diagnosed with ISSNHL who were admitted to the otorhinolaryngology ward of Zhejiang Provincial Hospital of Traditional Chinese Medicine from January 2020 to December 2023 were included. Univariate and multivariate logistic regression analyses were employed to identify independent prognostic factors for the treatment outcome of ISSNHL, which were subsequently used to develop nomograms. Discrimination, calibration, and clinical utility were assessed to evaluate the performance of the ISSNHL nomograms. 371 ISSNHL patients were enrolled in this study. Multivariable logistic regression analysis showed that history of deafness, aural fullness, time of onset, and age were independent prognostic factors for ISSNHL patients, with statistically significant regression coefficients. Predictive nomograms were developed with excellent discrimination, calibration, and clinical value. Leveraging data from ISSNHL patients, we developed a predictive nomogram to assess prognostic factors upon admission. This nomogram facilitates clinicians in approximating the likelihood of favorable prognosis. By accumulating clinical data from ISSNHL patients, it's anticipated that the possibility of recovery following treatment can be determined.
Pubmed PDF WebXiaoYan Le JingJing Liu QiaoFei Jia JiaYuan Wu YiZhen Jiang ZhengGang Lv Department of Otolaryngology, Dongyang People’s Hospital, Zhejiang, China
Publication date 02-07-2024
The effect of batroxobin on hearing recovery in patients with Sudden Sensorineural Hearing Loss (SSNHL) is still controversial, and acupuncture shows auxiliary benefits for SSNHL. To investigate the effectiveness of combining acupuncture with batroxobin therapy for patients with SSNHL. One hundred and fifty-six patients with SSNHL were retrospectively enrolled in this study, and categorized into the control group (only batroxobin treatment) and observation group (batroxobin and acupuncture treatment). Pure Tone Audiograms (PTA) threshold and clinical outcomes of hearing recovery were compared. Logistic regression analysis was used to evaluate the association between hearing recovery and potential risk factors. Compared to the control group, the observation group had a higher overall effective rate ( Combining batroxobin and acupuncture treatments enhences the improvement of hearing recovery in SSNHL patients compared to only batroxobin treatments, especially high-frequency and flat-type hearing loss.
Pubmed PDF WebVahit Mutlu Zulkuf Kaya Department of Otorhinolaryngology, Medical Faculty of Atatürk University, Erzurum, Turkey
Publication date 02-07-2024
The most important problem in tonsillectomy is pain in the early postoperative period. We purposed to compare the effects of lidocaine, tetracaine, and articaine application to the peritonsillar bed on post-tonsillectomy pain in children. The prospective, placebo-controlled study included 80 patients, ages 3-14, who were scheduled for elective tonsillectomy. Patients were randomly divided into four groups. Group 1 received 0.9% Na Cl; group 2 received 2% lidocaine; group 3 received 2% tetracaine; and group 4 received 4% articaine to the tonsillary bed for 5 min just after the operation. All patients were evaluated in terms of pain and pain-related adverse events in the postoperative 24 h. All groups that used local anesthetics had significantly lower pain levels than the control group in the first eight hours ( We recommend the immediate application of topical articaine to the tonsillar bed following the procedure to enhance postoperative pain management.
Pubmed PDF WebMichihiko Sone Nobutaka Ohgami Naomi Katayama Masumi Kobayashi Yishuo Gu Keming Tong Tadao Yoshida Shinji Naganawa Masashi Kato a Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japanb Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japanc Department of Health and Nutrition, Nagoya Women’s Univerisity, Nagoya, Japand Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Publication date 24-06-2024
Although various medical remedies have been attempted to alleviate the symptoms of Meniere's disease (MD), the risk-benefit ratios of these various treatments remain debatable. We investigated the efficacy of sound stimulation of 100 Hz for treating vestibular dysfunction in patients with Meniere's disease (MD). Patients with definitive MD with intractable vestibular symptoms and endolymphatic hydrops (EH) in the inner ear were evaluated. The experimental group received sound stimulation of 75 dB at a frequency of 100 Hz for 5 min, and the control group received sound stimulation of 75 dB at a frequency of 250 Hz for 5 min. Cervical vestibular-evoked myogenic potentials (cVEMPs) were measured before and after each sound stimulation, and the results of the clinical tests were compared between the two patient groups. Significant increases in cVEMP amplitudes were observed after sound stimulation of 100 Hz in ears with vestibular endolymphatic hydrops, although no such improvement was observed in the control group. Sound stimulation of 75 dB at a frequency of 100 Hz leads to improvement in cVEMP amplitude in patients with definitive MD. Adequate sound stimulation might be a new method for treating vestibular dysfunction associated with MD.
Pubmed PDF WebPing-Chia Cheng Po-Hsuan Wu Chih-Ming Chang Wu-Chia Lo Li-Jen Liao Yi-Ho Young Po-Wen Cheng a Department of Otolaryngology Head and Neck Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwanb Department of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwanc Department of Electrical Engineering, Yuan Ze University, Taoyuan, Taiwand Graduate Institute of Medicine, Yuan Ze University, Taoyuan, Taiwan
Publication date 15-07-2024
Many studies have discussed the betahistine treatment for Meniere's disease (MD). However, regarding cochlear MD, there is no consensus on the long-term betahistine treatment. This study aims to investigate the relationship between the betahistine treatment duration in patients with cochlear MD and their clinical outcomes. We enrolled 78 patients with 96 ears who were diagnosed with cochlear MD and received the treatment for more than 6 months. Outcomes included the hearing status, frequency of acute hearing loss attack, and whether the disease progressed to MD. Clinical characteristics including age, sex, side of affected ear, treatment duration of betahistine and trichlormethiazide, and pre-treatment hearing level was recorded from medical charts. Comparing the clinical characteristics by outcomes, the average betahistine treatment duration was the independent factor for hearing status of four-tone average ( For patients with cochlear MD, regular and long-term betahistine treatment can benefit their hearing outcome in the low- and medium-frequency.
Pubmed PDF WebZi-meng Wang Si-yu Zhu Qin Wang Chong-yang Duan Si-han Liu Rui You Ming-Yuan Chen Pei-Yu Huang a State Key Laboratory of Oncology in South China, Guangzhou, Chinab Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Chinac Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Chinad Sun Yat-sen University Cancer Center, Guangzhou, Chinae Department of Biostatistics, School of Public Health, Southern Medical University, Guangzhou, Chinaf Nasopharyngeal Cancer Center, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China
Publication date 21-07-2024
Keratinizing squamous cell carcinoma (KSCC) is recognized as WHO I nasopharyngeal carcinoma (NPC). Current guidelines for treating nasopharyngeal cancer do not delineate specific strategies for individual pathologic subtypes. To explore the optimal treatment for KSCC of the nasopharynx. Data on patients were extracted from the SEER database. Survival differences between patients treated with radiotherapy alone and combined surgery were assessed using Kaplan-Meier and Cox regression models and compared using propensity score matching (PSM). In addition, we explored the survival differences between the two groups of patients in different risk stratifications. In our study, 165 patients underwent surgical intervention, while 1238 patients did not. In both univariate (CSS: For patients diagnosed with WHO I nasopharyngeal carcinoma, the combination of radiotherapy and surgery has significant clinical advantages, especially for patients at high risk.
Pubmed PDF WebDaogong Zhang Zhaomin Fan Yafeng Lv Ling Lu Maoli Duan Haibo Wang a Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Chinab Shandong Provincial Vertigo and Dizziness Medical Center, Jinan, Chinac Shandong Institute of Otorhinolaryngology, Jinan, Chinad Department of Otolaryngology-Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Chinae Ear Nose and Throat Patient Area, Trauma and Reparative Medicine Theme, Karolinska University Hospital, Stockholm, Swedenf Division of Ear, Nose and Throat Diseases, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
Publication date 20-06-2024
Marcos V. Goycoolea Raquel Levy Pilar Alarcón Catherine Catenacci Gloria Ribalta Byanka Cagnacci Rosario Garrido Elisa Varas José Manuel Zúñiga a Department of Otolaryngology, Clínica Universidad de Los Andes, Santiago, Chileb Department of Otolaryngology, Clínica Las Condes, Santiago, Chilec Department of Otolaryngology, Clínica Meds, Santiago, Chiled Latin American Division, Cochlear Latin America, Panama
Publication date 17-11-2023
Cochlear implants are standard of care for the patients with sensorineural hearing loss not benefited from hearing aids. Evaluate qualitatively the impact of cochlear implantation in the long-term. Thirty middle-class patients with similar patterns of loss and social environment averaging 20 years post-implantation responded to 52 questions that evaluated psychosocial benefits from cochlear implantation. All completed secondary education and 93% had postgraduate studies. Educational and workwise they are at the same level as their hearing counterparts. All use their cochlear implants and would recommend one to people who need it. They attribute their success to the implant, the rehabilitation program, their family, and a stimulating social environment. Despite their success, most experience difficulties relating with others (socially and at work) due to their hearing condition. They manage but work much harder than their hearing peers to achieve the same. We made a difference in the lives of these patients, however, there is more to be done. Early intervention, rehabilitation, plus family, and stimulating-environment are crucial in children with sensory deficits.
Pubmed PDF WebRasheed Omobolaji Alabi Alhadi Almangush Mohammed Elmusrati Ilmo Leivo Antti A. Mäkitie a Research Program in Systems Oncology, University of Helsinki, Helsinki, Finlandb Department of Industrial Digitalization, School of Technology and Innovations, University of Vaasa, Vaasa, Finlandc Department of Pathology, University of Helsinki, Helsinki, Finlandd Institute of Biomedicine, University of Turku, Pathology, Finlande Department of Otorhinolaryngology – Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finlandf Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden
Publication date 28-01-2024
The mortality rates of laryngeal squamous cell carcinoma cancer (LSCC) have not significantly decreased in the last decades.
Pubmed PDF WebPelle Hanberg Trine Tramm Arunas Pikelis Sten Schytte Søren Dürr Gade Tejs Ehlers Klug a Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Aarhus, Denmarkb Department of Clinical Medicine, Aarhus University, Aarhus, Denmarkc Department of Otorhinolaryngology, Head and Neck Surgery, Aalborg University Hospital, Aalborg, Denmarkd Department of Pathology, Aarhus University Hospital, Aarhus, Denmark
Publication date 23-07-2024
Studies suggest that neck dissections with a minimum of 16-18 yielded nodes are associated with better overall survival compared to neck dissections with lower yields. We aimed to identify factors affecting the lymph node yield and density in patients with oral cavity cancer undergoing elective neck dissection levels 1-3. Using prospectively registered data, we conducted a population-based cohort study on all patients surgically treated for oral cavity cancer including levels 1-3 neck dissection at our institution from 2018 to 2022. Uni and multivariate analyses were performed to identify factors associated with lymph node yields. In total, 221 patients were included. The mean lymph nodes yield and density were 19 (95%CI 18-20) and 0.12 (95%CI 0.09-0.16), respectively. In multivariate analysis, increasing body weight ( Increasing body weight was positively and previous radiotherapy was negatively correlated to lymph node yield. These factors should be taken into consideration when interpreting the lymph node yield as an indicator of neck dissection quality.
Pubmed PDF WebTaru Ilmarinen Åse Bratland Hanne Tøndel Arnar Guðjónsson Maria Gebre-Medhin Björn Palmgren Hanna Mäenpää Kristine Bjørndal Jesper Grau Eriksen a Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finlandb Department of Oncology, Oslo University Hospital, Oslo, Norwayc Department of Oncology, St. Olavs Hospital, Trondheim, Norwayd Department of Otorhinolaryngology-Head and Neck Surgery, Landspitali University Hospital, Reykjavik, Icelande Department of Hematology, Oncology, and Radiation Physics, Skåne University Hospital, Lund, Swedenf Department of Otorhinolaryngology-Head and Neck Surgery, Karolinska University Hospital, Stockholm, Swedeng Department of Oncology, Tampere University Hospital, Tampere, Finlandh Department of Otorhinolaryngology – Head and Neck Surgery, Odense University Hospital, Odense, Denmarki Department of Oncology, Aarhus University Hospital, Aarhus, Denmarkj Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
Publication date 07-08-2024
All Nordic countries have national cancer registries collecting data on head and neck cancer (HNC) incidence and survival. However, there is a lack of consensus on how other quality aspects should be monitored. We conducted a web-based survey to find opportunities for quality control and improvement. A web-based survey was sent to one otorhinolaryngology - head and neck (ORL-HN) surgeon, and one oncologist at each Nordic university hospital treating HNC. In total, 42 responses from all 21 university hospitals were included. In over half of the university hospitals, an oncologist, an ORL-HN surgeon, a pathologist, a radiologist, and a specialized nurse was always present at the multidisciplinary tumor board (MTB) meeting. Of 42 respondents 35 (83%) agreed that treatment delays were systematically recorded for each patient. Eleven of 21 (52%) oncologists agreed that side-effects of (chemo)radiotherapy were systematically recorded. Less than half of the respondents agreed that complications of surgery, and post-treatment quality of life (QOL) were systematically recorded. In the Nordic countries, the importance of HNC treatment timelines is well acknowledged. There is a lack of consensus on the composition of MTB meeting, and how treatment-related morbidity should be monitored outside clinical trials.
Pubmed PDF WebBerrak Güven Duygu Erdem a Department of Biochemistry, Faculty of Medicine, Zonguldak Bulent Ecevit University, Zonguldak, Turkeyb Department of Otorhinolaryngology, Faculty of Medicine, Zonguldak Bulent Ecevit University, Zonguldak, Turkey
Publication date 09-08-2024
HE4 and CA 125 are identified as a potential biomarker for the detection of some diseases with fibrosis. The purpose of this pilot study was to evaluate the value of human epididymis protein 4 (HE4) and cancer antigen-125 (CA-125) in otosclerosis patients. The study population consisted of 60 people (30 otosclerosis patients, 30 control group). We collected blood samples for HE4 and CA-125 levels. Serum HE4 and CA-125 levels were measured by enzyme-linked immunosorbent assay (ELISA). We compared the results between otosclerosis patients and the normal subject. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve was performed to evaluate the diagnostic value. There was no differences in CA-125 level between the otosclerosis (20.3 U/mL [10.4-42.1] and control group (19.3 U/mL [15.3-49.8]) ( Serum HE4 level may be a useful biomarker in otosclerosis. Further studies with a larger number of patients are required to confirm our pilot results.
Pubmed PDF WebWoo Hee Lee Yukinori Takenaka Kiyohito Hosokawa Hirotaka Eguchi Masami Suzuki Takahito Fukusumi Motoyuki Suzuki Hidenori Inohara Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
Publication date 10-08-2024
Lactate dehydrogenase (LDH) is involved in the Warburg effect. Elevated serum LDH is a prognostic marker for metastatic solid cancer. To investigate the prognostic impact of serum LDH in patients with head and neck squamous cell carcinoma treated with immune checkpoint inhibitors (ICIs). This retrospective study included 129 patients treated with ICIs between 2017 and 2023. The effects of pretreatment LDH, LDH at 3 months, and change in LDH during the first 3 months (ΔLDH) on overall survival (OS) and progression-free survival (PFS) were analyzed using the Kaplan-Meier method and Cox regression model. The 1-year PFS and OS rates for high and low groups were 6.0% and 30.1% for pretreatment LDH ( ΔLDH can be used to predict ICI treatment outcomes and as a marker in deciding to continue ICI therapy.
Pubmed PDF WebXiaoping Qiu Xin Wang Jian ShangGuan Zhipeng Xu a Department of Otorhinolaryngology-Head and Neck Surgery, Shaanxi Provincial People’s Hospital, Xi’an, Chinab Department of Oral and Maxillofacial Surgery, Shaanxi Provincial People’s Hospital, Xi’an, China
Publication date 10-08-2024
Cervical necrotizing fasciitis (CNF) is a life-threatening bacterial infection with a diagnostic challenge. Currently, there is insufficient evidence on the diagnostic accuracy of inflammatory indicators in CNF. This study aims to identify key inflammatory indicators and assess their diagnostic accuracy for CNF. A diagnostic case-control study was conducted at a tertiary healthcare facility from January 2020 to December 2023. Laboratory data from patients with CNF and non-CNF at admission were evaluated. Key inflammatory indicators were identified through consistent outcomes from multivariable logistic regression and receiver operating characteristic curves analyses. The diagnostic accuracy of these indicators, with the results of combined tests, were calculated. CNF was confirmed in 21 of the 67 patients investigated. C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR) were identified as key inflammatory indicators, with sensitivities of 0.905 and 0.810, and specificities of 0.870 and 0.913, respectively, at CRP threshold of 165.0 mg/L and NLR of 15.8. Combining CRP and NLR in parallel and serial tests increased sensitivity to 0.952 and specificity to 1.0, respectively. CRP and NLR have been verified as key inflammatory indicators with satisfactory diagnostic abilities for CNF diagnosis, providing a strong foundation for future studies.
Pubmed PDF WebOnur Erçelik Hatice Karadaş Zeynep Kaptan Akif Sinan Bilgen Pelin Samaraz Olgun Muzaffer Çaydere Sema Hücümenoğlu a Department of Otolaryngology-Head and Neck Surgery, Bandırma State Hospital, Bandırma, Balıkesir, Turkeyb Department of Otolaryngology-Head and Neck Surgery, Ankara Research and Training Hospital, Ankara, Turkeyc Department of Otolaryngology-Head and Neck Surgery, Kırşehir Research and Training Hospital, Kırşehir, Turkeyd Department of Pathology, Ankara Research and Training Hospital, Ankara, Turkey
Publication date 14-08-2024
Stromal Vascular fraction/gel (SVF/gel) is prepared mechanically from autologous adipose tissue, and it is known for its regenerative and anti-inflammatory properties. To assess histopathological effects of adipose tissue-derived SVF/gel and nasal steroids on nasal mucosal healing. Forty-two Wistar Albino rats with right nasal mucosal injury were randomly divided into three groups: control (saline), Mometasone Furoate (MF), and SVF/gel. Control group ( When comparing the MF and SVF/gel groups, statistically significant differences were found on day 14 in indices of epithelial thickness, subepithelial thickness, goblet cells, subepithelial fibrosis, and ciliated cells. On day 28, SVF/gel group exhibited higher ciliated cell counts and lower subepithelial fibrosis values ( SVF/gel accelerates re-epithelialization, reduces fibrosis and adhesions, and enhances cilia formation compared to nasal steroids. These findings suggest that SVF/gel is an autologous and cost-effective treatment for improving nasal mucosal healing post-injury.
Pubmed PDF WebAna Margarida Amorim Diliana Rebelo Ana Beatriz Ramada Ana Cristina Lopes João Lemos João Carlos Ribeiro a Otorhinolaringology Department, Coimbra Local Health Unit, EPE, Coimbra, Portugalb Faculty of Medicine, Coimbra University, Coimbra, Portugalc Neurology Department, Coimbra Local Health Unit, EPE, Coimbra, PortugalAna Margarida Costa Redondo Cancela de Amorim, Department of Otorhinolaryngology, Coimbra Local Health Unit, EPE, Faculty of Medicine, University of Coimbra, Portugal, E-mail: marge_c_amorim@yahoo.comDiliana Rebelo, Department of Otorhinolaryngology, Coimbra Local Health Unit, EPE, E-mail: diliana.rebelo@gmail.comAna Beatriz Ramada, Department of Otorhinolaryngology, Coimbra Local Health Unit, EPE, E-mail: beatrizramada@gmail.comAna Cristina Lopes, Department of Otorhinolaryngology, Coimbra Local Health Unit, EPE, E-mail: ana.crisfl@hotmail.comJoão Manuel Lemos, Department of Neurology, Coimbra Local Health Unit, EPE, Faculty of Medicine, University of Coimbra, Portugal, E-mail: merrin72@hotmail.comJoão Carlos Gomes Silva Ribeiro, Department of Otorhinolaryngology, Coimbra Local Health Unit, EPE, Faculty of Medicine, University of Coimbra, Portugal, E-mail: jcarlosribeiro@uc.pt
Publication date 16-08-2024
Usher's syndrome type II (USH2) is a rare genetic disorder encompassing hearing loss, vision impairment, and apparent intact vestibular function. Recent research suggests a potential involvement of the otolith vestibular receptors in USH2. Evaluate otolith dynamic function in USH2. Twenty-two USH2 (median age 53.9 ± 2.99) and age-matched controls underwent a complete battery vestibular testing including air conducted cervical and ocular vestibular evoked myogenic potentials (c-VEMPs and o-VEMPs). Vestibular function tests were correlated with Activities Balance Scale (ABC) and Dizziness Handicap Inventory (DHI) scores. Fourteen USH2 reported previous vertigo (vs none control). Among 88 ears, c-VEMPs were absent in 15 USH2 cases and 4 controls ( Our findings suggest the presence of otolith dysfunction in USH2, which is independent from subjectively reported dizziness. Incorporating vestibular testing into USH2 evaluation and monitoring could enhance characterization of this multisensory disease.
Pubmed PDF WebDi Liu Xuesong Wang Wenwen Zhou Anzhou Tang Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Publication date 18-08-2024
Cochlear dimension measurements are critical in diagnosing and managing congenital sensorineural hearing loss. To evaluate the feasibility and reliability of an automated landmark approach for measuring cochlear dimensions (A-, B- and H-values). Cochlear parameters from 100 patients were measured by MPR, manual three-dimensional and ALPACA. We assessed intra- and inter-observer reliability as well as inter-method reliability. Statistical analyses were conducted to detect differences between the right and left ears, as well as to assess the relevance of the values obtained using ALPACA. All A-, B-, and H-values measured by the various methods showed a high intra-observer reliability with intra-class correlation coefficients (ICC) ranging from 0.70 to 0.99, and values gained by ALPACA reaching the highest ICC. Inter-method reliability was at a good level with ICC ranging from 0.51 to 0.86. There were no significant differences between the right and left ears' measured values. Obvious positive correlations existed among cochlear dimensions measured by ALPACA. The ALPACA method can be used to measure cochlear dimensions. Values obtained by the method demonstrate high reliability and consistency with a significant reduction in intra-observer variability compared to results from conventional MPR and manual 3D measurements.
Pubmed PDF WebQingqing Xia Jiyue Chen Yi Zheng Shiming Yang Fei Ji a College of Medicine, Nankai University, Tianjin, Chinab Senior Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, Chinac State Key Laboratory of Hearing and Balance Science, Beijing, Chinad National Clinical Research Center for Otolaryngologic Diseases, Beijing, Chinae Key Laboratory of Hearing Science, Ministry of Education, Beijing, Chinaf Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing, Chinag Beihang University, Beijing, China
Publication date 28-08-2024
An objective measurement of speech perception would be valuable in hearing-impaired patients who are unable to perform auditory tasks reliably. To investigate the feasibility of cortical auditory evoked potentials (CAEPs) evoked by different spectro-temporal modulation (STM) signals and provide reference for the further exploration of acoustic change complex (ACC) in hearing-impaired patients. 29 normal hearing (NH) adults were recruited and stimulated randomly by STM signals at 6 spectral modulation rates: 0, 1, 2, 4, 8, 16 cycles/octave, at each of 4 temporal modulation rates: 0, 2, 4, 8 Hz, to elicit ACC response. The change of spectral modulation rates ≤ 16 cycles/octave at 0 Hz temporal modulation rate had different impacts on latency. 0, 1 cycles/octave, and 4, 8 Hz made a difference to the P2-N1 amplitude easily. 8, 16 cycles/octave were more unstable in rejection rate. No significant difference existed in waveform repetition rate among different STM rates. No significant interaction effect existed in spectral and temporal modulation. STM as a stimulus signal to induce ACC response had its feasibility. 2 cycles/octave at spectral modulation rate and 2 Hz at temporal modulation rate had better stability and waveform repeatability in NH adults.
Pubmed PDF WebSemih Karaketir Güler Berkiten Belgin Tutar Onur Akan Tolgar Lütfi Kumral Hüseyin Sari Yavuz Atar Ayşe Enise Göker İsmail Abdullahi Ahmed Cem Çelik Yavuz Uyar a Department of Otorhinolaryngology, Kozyatağı Central Hospital, Istanbul, Turkeyb Department of Otorhinolaryngology, University of Health Sciences, Prof. Dr. Cemil Taşçıoğlu City Hospital, Istanbul, Turkeyc Department of Neurology, University of Health Sciences, Prof. Dr. Cemil Taşçıoğlu City Hospital, Istanbul, Turkeyd Faculty of Medicine, Department of Otorhinolaryngology, Üsküdar University, Istanbul, Turkeye Department of Otorhinolaryngology, Haliç University, Avcilar Hospital, Istanbul, Turkey
Publication date 03-09-2024
Idiopathic intracranial hypertension (IIH) can affect both hearing and balance due to increased inner ear pressure. This study aimed to evaluate the impact of increased inner ear pressure on hearing and balance in patients with IIH using auditory and vestibular tests. Twenty-four IIH patients and 28 healthy controls underwent oVEMP, pure tone audiometry, tympanometry, and acoustic reflex tests pre-lumbar punctures. IIH patients received acetazolamide. Pre- and post-treatment results, tinnitus, and vertigo scores were compared. Post-treatment oVEMP and audiometry results were compared between groups. Pre-treatment oVEMP showed a significant left N1 latency difference ( Prolonged oVEMP latency suggests IIH may impact the brain stem and vestibular nerve, while increased amplitude values indicate peripheral vestibular involvement. IIH affects hearing across all frequencies, especially at 4000 Hz, impacting both hearing and balance. Understanding the effects of IIH on auditory and vestibular functions can guide effective treatments, improving quality of life for patients by addressing both hearing and balance issues.
Pubmed PDF WebSang-Yoon Han Sang-Yeon Lee Myung-Whan Suh Jun Ho Lee Moo Kyun Park a Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Republic of Koreab Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Republic of Koreac Sensory Organ Research Institute, Seoul National University, Medical Research Center, Seoul, Republic of Korea
Publication date 03-09-2024
Eosinophilic otitis media (EOM) is an intractable condition primarily treated with steroids. Recently, biologics targeting IgE or IL-5 have been introduced. This study aimed to evaluate the efficacy of biologics for EOM. We retrospectively collected data on EOM patients treated from January 2008 to December 2020 from electronic medical records. Patients were classified into the steroid group, treated with systemic or local steroids, and the biologics group, treated with biologics with or without steroids. The otorrhea remission rate was 63.33% in the steroid group, comparable to 58.82% in the biologics group ( Biologics demonstrated similar efficacy in otorrhea remission as steroids and might help maintain hearing levels. Biologics can be considered for controlling EOM with active otorrhea and reducing systemic steroid use.
Pubmed PDF WebYangming Leng Wenliang Fan Yingzhao Liu Renhong Zhou Ying Shen Hui Ma Bo Liu a Department of Otorhinolaryngology-Head and Neck Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR Chinab Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR Chinac Hubei Province Key Laboratory of Molecular Imaging, Wuhan, PR Chinad Department of Otorhinolaryngology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, PR China
Publication date 07-09-2024
Patients with delayed endolymphatic hydrops (DEH) often show caloric hypofunction and endolymphatic hydrops (ELH) on gadolinium (Gd) enhanced magnetic resonance imaging (MRI) of the inner ear. We aimed to investigate the relationship between the ELH Twelve patients with ipsilateral DEH were included, who underwent delayed MRI following intratympanic Gd application, pure-tone audiometry, caloric test, and video head impulse test (vHIT). For the affected ears, the overall prevalence of inner ear hydrops was 91.7%, including 75% in the cochlear and 50% in vestibular compartment. For the non-affected ears, the overall prevalence of inner ear hydrops was 25%, including 25% in cochlear and 16.7% in vestibular region. Caloric hypofunction was demonstrated in 75% of the affected ears. No pathologic vHIT were found. Caloric results were in agreement with the radiological evidence of inner ear hydrops on affected and non-affected ears in 9 cases. There was fair concordance between inner ear hydrops and canal paresis abnormality on the affected side. MRI provides auxiliary evidence of ELH
Pubmed PDF WebFranz Muigg Philipp Zelger Josef Seebacher Joachim Schmutzhard Viktor W. Weichbold a University Hospital for Hearing, Speech and Voice Disorders, Medical University of Innsbruck, Innsbruck, Austriab University Hospital of Otorhinolaryngology, Medical University of Innsbruck, Innsbruck, Austria
Publication date 09-09-2024
Previous studies found that in patients with profound hearing loss the NEO- personality factor Openness-to-experience is lowered. Assuming that lowered Openness-to-experience may be due to limited access to sounds, we hypothesized that levels of Openness-to-experience would increase in these patients after cochlear implantation. Twenty adults (mean age: 61 years; active CI users) with bilateral profound hearing loss were assessed with the NEO-Five-Factor-Inventory before cochlear implantation (pre) and five years later (post). No significant pre-post changes in personality were seen. Both before and five years after cochlear implantation, the sample had normal age- and gender-specific mean values on the factors Extraversion, Neuroticism, Agreeableness, and Conscientiousness (T ≈ 50), but significantly lowered mean values on Openness-to-experience (T ≈ 42, Cochlear implantation apparently has no (or at best very little) effect on Openness-to-experience in profoundly hearing impaired patients. While this study demonstrates once again, that high-grade hearing loss may be associated with less openness to new experiences, the reason for this association remains unclear.
Pubmed PDF WebElnaz Sepehri Bo Tideholm Sten Hellström Cecilia Engmér Berglin a Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Swedenb Division of Ear, Nose and Throat Diseases, Hearing and Balance, Karolinska University Hospital, Stockholm, Sweden
Publication date 12-09-2024
There is a need for a simpler and accessible intervention to heal tympanic membrane perforations than myringoplasty that is todaýs golden standard. Experimental studies have identified plasminogen as a promising agent for medical treatment of chronic tympanic membrane perforation. This was a phase 1, prospective, randomized, placebo-controlled study with the main objective to evaluate the safety of injecting plasminogen in the vicinity of the tympanic membrane in subjects with chronic tympanic membrane perforation. Adults diagnosed with a dry chronic tympanic membrane perforation were recruited for an injection schedule with Human plasminogen 10. Adverse events, audiometry, VAS fluctuations and size of perforation, were monitored throughout the length of the study. It was possible to perform the injections according to schedule in all subjects. None of the subjects experienced any severe adverse events. Most common adverse event was ear pain. No signs of ototoxicity were reported. This pilot study suggests that plasminogen injections close to the tympanic membrane as treatment for chronic tympanic membrane injections are safe and feasible, encouraging further dose-escalating studies.
Pubmed PDF WebKarin Hallin Ulrika Larsson Elsa Erixon Department of Surgical Sciences, Otorhinolaryngology and Head and Neck Surgery, Uppsala University, Uppsala, Sweden
Publication date 07-08-2024
To decide what programming parameters to use for cochlear implants (CIs) in partial deaf patients can be challenging. The processor programming form, categorised as electrical complement (EC), electro-acoustic-stimulation (EAS) or electric stimulation (ES), and difficulties switching programming form were investigated. A retrospective investigation of medical records and audiograms was conducted in adult patients intended for EC and EAS. Eighty-four ears (80 patients) were included. Twenty ears were initially fitted with EC, 32 with EAS, 30 with ES and 2 with both EC and EAS. Sixty-four ears met the criteria to use EC or EAS at initial fitting, however only 54 ears were fitted with EC or EAS initially. Twenty-eight patients altered between at least two programming forms and six of those experienced difficulties to adapt to a new form when their low-frequency hearing deteriorated. Twenty-five percent of patients initially fitted with EC or EAS switched programming form within two years. Further studies on how to choose the most beneficial sound processor programming parameters for EC and EAS, and when to change between programming forms, are warranted as well as clear guidance on choosing the right candidates for EC and EAS.
Pubmed PDF WebSeiichiro Makihara Kensuke Uraguchi Shohei Fujimoto Aiko Shimizu Shin Kariya Mitsuhiro Okano Takashi Yorifuji Mizuo Ando a Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japanb Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japanc Department of Otolaryngology, Kawasaki Medical School, Kurashiki, Japand Department of Otolaryngology, School of Medicine, International University of Health and Welfare, Narita, Japan
Publication date 12-08-2024
In 2013, Japan established a standardized classification system for categorizing endoscopic sinus surgery (ESS) into types I-V, yet no evaluation has been conducted thereof. We assessed the ESS trends and status in Japan, focusing on outpatient and inpatient surgeries. This descriptive retrospective cohort study used Japan's National Database of Health Insurance Claims and Specific Health Checkups between 2014 and 2021. The distribution of ESS types I-V and outpatient and inpatient surgeries was analysed, along with age groups and regional differences, focusing on ESS type III. Overall, 427,813 ESS procedures were performed, with types III and IV being most common. Outpatient ESS type III increased substantially compared to inpatient surgeries. Younger individuals favoured outpatient ESS type III over inpatient surgeries, with substantial regional variations across prefectures. The adoption of a standardized ESS classification in Japan has facilitated a detailed understanding of surgical trends. The shift toward outpatient surgeries, especially for type III ESS, aligns with global trends toward minimally invasive procedures and reflects changing patient preferences and healthcare delivery practices. Consequently, continuous monitoring and research are crucial for adapting surgical practices to the evolving healthcare needs and patient expectations.
Pubmed PDF WebYan Zhang Zichen Chen Yuzhong Zhang Feiyun Chen Ying Gao Juan Hu Junli Wang Maoli Duan Qing Zhang a Department of Otolaryngology Head & Neck Surgery, Second Affiliated Hospital of Xi’an Jiaotong University, School of Medicine, Xi’an, Shaanxi, Chinab Department of Clinical Science, Intervention and Technology, department of Otolaryngology Head and Neck Surgery & Audiology and Neurotology, Karolinska University Hospital, Karolinska Institute, Stockholm, Swedenc Department of Otorhinolaryngology-Head & Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, Chinad Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, Chinae Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Publication date 03-09-2024
Unlike air-conducted sounds (ACS) and bone-conducted vibration (BCV), galvanic vestibular stimulation (GVS) evokes vestibular evoked myogenic potentials (VEMPs) from the vestibular nerve. Case-control study was conducted in unilateral VS patients pre-operatively. Healthy ears were controls. Patients examined ACS, BCV and GVS ocular VEMP (oVEMP) and cervical VEMP (cVEMP), caloric test, video head impulse test (vHIT), suppression head impulse paradigm (SHIMP) and pure tone audiometry (PTA). Seven (26.9%) tumors affected left ear and 19 (73.1%) on the right( Response rates of GVS VEMPs decreased with the residual functional nerve fibers. GVS VEMPs help to differentiating labyrinthine and retro-labyrinthine lesions. GVS combined with BCV VEMPs probably reflex the tumor origin from the eighth cranial nerve and/or the remaining vestibular function.
Pubmed PDF WebAntoine Dubray-Vautrin Benjamin Vérillaud Philippe Herman Romain Kania a Department of Oto-Rhino-Laryngology, Head & Neck Surgery, Center of Neurosensorial-Head&Neck Diseases, Lariboisière Hospital, University of Paris Cité, Assistance Publique des Hôpitaux de Paris & UMR 1141 Center for the Developing Brain, Paris Biobank BB-0033-00064, Platform of Biopathology and Innovative Technologies for Health, Paris, Franceb Department of Oto-Rhino-Laryngology, Head & Neck Surgery, Institut Curie, Paris, France
Publication date 12-02-2024
Squamous cell carcinoma (SCC) of the temporal bone (TB) is a rare pathology originating from the external auditory canal (EAC). Surgery remains the gold standard to achieve local control.
Aims/Objectives:The aim of this study was to evaluate overall survival (OS) and disease-free survival (DFS) after surgery of the SCC of EAC.
A retrospective chart review in a tertiary referral center included 26 patients: 23 were operated with lateral temporal bone resection (LTBR,
Adjuvant radiotherapy was performed in 91.3% (
En bloc surgical resection with free margins, coupled with postoperative radiotherapy, provides optimal local control. For stage IV tumors, where complete margins are achievable, ETBR is recommended to enhance local control.
Yu-Xin Zhang Xin-Ying Niu Zhi-Yong Xiao Meng-Ting Wang Hui Zheng a The Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Wenjiang District, Chinab Chengdu Xinan Gynecology Hospital, Sichuan Jinxin Xinan Women’s & Children’s Hospital (Bisheng), Chengdu, Chinac Chengdu University of Traditional Chinese Medicine, Chengdu, Wenjiang District, China
Publication date 03-09-2024
Scopolamine has been demonstrated to relieve motion sickness. However, repeated significance testing may increase false-positive results. Review the efficacy and safety of scopolamine in the prevention of motion sickness by performing a meta-analysis with Trial Sequential Analysis (TSA). Randomized controlled trials (RCTs) compared scopolamine with other medications or placebo were included. Primary outcomes were nausea reported and head movement time. Twenty studies with 753 participants were included. Scopolamine had a greater reported reduction in nausea than placebo (relative risk [RR] 0.35; 95% confidence interval [CI] 0.24 to 0.52; Scopolamine is effective for motion sickness nausea compared to placebo. The TSA recommends conducting more head movement trials to validate the objective efficacy of scopolamine. Clarifying the efficacy of scopolamine for motion sickness, the TSA highlights the need for more prospective studies using head movement as an outcome.
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