Karin Hallin Ulrika Larsson Nadine Schart-Morén Department of Surgical Sciences, Otorhinolaryngology and Head and Neck Surgery, Uppsala University, Uppsala, Sweden
Publication date 01-10-2024
Hearing can be preserved in patients with considerable low-frequency hearing implanted with cochlear implants. However, the most favorable electrode type for hearing preservation and speech perception has been debated. The aim was to evaluate hearing preservation and speech discrimination one year post-implantation for all types of cochlear implant electrode used for adult patients implanted between 2014 and 2022. The HEARING group formula was used to calculate the degree of hearing preservation, which was defined as minimal (0-25%), partial (25-75%) or complete (≥ 75%). Speech perception was measured by monosyllabic words. Analysis of hearing preservation for the various electrode types revealed that FLEX 24 preserved hearing statistically significantly better ( There was a statistically significant difference between the electrode types in terms of hearing preservation but not for speech perception. The result of this study contributes important information about hearing preservation and speech perception that can be used for pre-surgery patient counselling.
Pubmed PDF WebToshiyuki Matsuyama Mizuki Sakurai Kazuaki Chikamatsu Department of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan
Publication date 04-10-2024
Anti-IL-4 receptor α antibody (dupilumab) has demonstrated favorable sinonasal outcomes for chronic rhinosinusitis with nasal polyps (CRSwNP), which is mainly caused by type 2 inflammation. Although increased blood eosinophil levels and injection site symptoms are frequently observed as acute adverse events (AEs) of dupilumab, limited knowledge is available regarding the late AEs of dupilumab for CRSwNP. We investigated the late AEs following the initiation of dupilumab treatment for CRSwNP. Fifty-one patients with CRSwNP treated with dupilumab for > 3 months were enrolled, and their clinical data were collected from their medical records. Six (11.8%) patients experienced late AEs. One case of eczema with pruritus, one case of psoriasis-like dermatitis, two cases of severe rash, one case of malignant lymphoma, and one case of alopecia areata were observed. Skin disorders were the most common late AEs in this study. It is a Th1-inflammatory disease, and its mechanism is thought to be due to the immune imbalance caused by dupilumab. We could not confirm whether malignant lymphoma in our case was caused by dupilumab use. Skin disorders are often late AEs associated with dupilumab; therefore, careful monitoring after dupilumab initiation should be considered.
Pubmed PDF WebMinfei Qian Zhuowei Yao Qixuan Wang Yaqi Zhou Zhiwu Huang Jiping Li a Department of Otolaryngology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Chinab Department of Otolaryngology Head and Neck Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Chinac Department of Otorhinolaryngology, Peking University Shenzhen Hospital, Shenzhen, China
Publication date 21-10-2024
Noise-induced cochlear synaptopathy has recently emerged as a focus in hearing research. This study aimed to examine the impact of repeated noise exposure on the quantification and mRNA expression levels of cochlear synapses. Measurements were conducted at baseline, 1 day, and 14 days post-exposure to 88 or 97 dB SPL noise (2 h/day for 7 days, frequency range 2-20 k Hz). Auditory brainstem responses (ABRs), immunofluorescence and quantitative real-time PCR (qRT-PCR) were used to examine the results. 1. Exposure to 88 dB SPL caused minimal changes in ABRs, ribbon morphology and medial olivocochlear (MOC) efferent synapses; elevation of synaptophysin(SYP) and α9α10 n AchR mRNA levels were observed. 2. Exposure to 97 dB SPL caused threshold shift and synaptopathy of ribbon and MOC; downregulation of α10n AchR, SYP and ctbp2 mRNA levels were observed. Noise-induced cochlear synaptic degeneration involves both afferent and efferent synaptopathy.
Pubmed PDF WebAo Li Xuan Yang Yuqin Xu Ning Zhao Xueyao Liu Haoliang Du Jifeng Xu Xia Gao Ye Yang a Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing, Chinab Department of Otolaryngology and Head-and-Neck Surgery, Nanjing Drum Tower Hospital, Drum Tower Clinical Medical College, Nanjing Medical University, Nanjing, Chinac Research Institute of Otolaryngology, Nanjing, Chinad Nanjing University of Information Science & Technology, Nanjing, China
Publication date 22-10-2024
Normative clinical values for wideband acoustic immittance (WAI) are not well-established. This study aims to define the normative contour plot characteristics of WAI and evaluate its diagnostic value in detecting tympanic effusion. Data were collected from subjects with normal hearing (76 ears) and type C tympanograms on 226-Hz tympanometry (130 ears). Matlab was used to process and analyze the data. The maximum absorbance of WAI was used as the primary indicator, and the receiver operating characteristic (ROC) curve was drawn to determine the optimal cut-off value. WAI contour plots were compared to 226-Hz tympanometry and otoendoscopy, the latter being the gold standard. Mean WAI plots in the normal group showed single peaks (absorbance, >70%) and a nearly symmetrical distribution of the peak area around the 0 da Pa pressure line. The ROC curve indicated an AUC value of 0.910, with 78% as the optimal cut-off value of maximum absorbance for detecting effusion. WAI demonstrated better diagnostic performance (sensitivity: 82.26%, specificity: 86.76%, kappa: 0.691) than 226-Hz tympanometry (sensitivity: 61.29%, specificity: 61.76%, kappa: 0.230). Normative WAI values were established, and WAI proved more accurate than 226-Hz tympanometry for identifying tympanic effusion, offering valuable guidance for selecting treatment options.
Pubmed PDF WebShin-ichi Usami Shin-ya Nishio Javier Gavilán Paul Van de Heyning Griet Mertens Eva Karltorp Henryk Skarżyński Abdulrahman Hagr Manikoth Manoj Hinrich Staecker Mario E. Zernotti Gunesh P. Rajan Joachim Müller Florian Simon Ilona Anderson a Department of Hearing Implant Sciences, Shinshu University School of Medicine, Matsumoto, Japanb Department of Otorhinolaryngology, La Paz University Hospital, Madrid, Spainc Department of Otorhinolaryngology Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgiumd Cochlear Implant Department, Karolinska University Hospital, Stockholm, Swedene Department of Teleaudiology and Screening, World Hearing Center of the Institute of Physiology and Pathology of Hearing, Kajetany, Polandf King Abdullah Ear Specialist Center, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabiag ENT Super Speciality Institute and Research Center, Kozhikode, Indiah Center for Hearing and Balance Disorders, Kansas University, Kansas City, KS, USAi Catholic University of Córdoba and National University of Córdoba, Córdoba, Argentinaj Faculty of Health Sciences and Medicine, University Hospital Lucerne, University of Lucerne, Luzern, Switzerlandk Otolaryngology, Head and Neck Surgery, Division of Surgery, Medical School University of Western Australia, Perth, Australial Department of Otorhinolaryngology, University Hospital, LMU Munich, Munich, Germanym Clinical Research Department, MED-EL GmbH, Innsbruck, Austria
Publication date 22-10-2024
While cochlear implantation (CI) and electric acoustic stimulation (EAS) have a positive outcome in most cases, their effectiveness varies depending on the etiology of the hearing loss. Among the various etiologies, genetic factors are the leading cause of hearing loss and may impact CI and EAS outcomes. To reveal the genetic background of the hearing loss in CI/EAS patients in each ethnic population, we undertook a multi-center study involving the genetic testing of hearing loss in CI/EAS patients from 10 centers. Saliva samples and clinical information for the patients and their family members were obtained and next-generation sequencing analysis using a panel carrying 63 deafness genes was then performed. Genetic testing successfully identified the causative gene variants in 54.5% (48/88) of patients with pre-lingual onset hearing loss (onset under 6 years) and in 12% (12/95) of those with late-onset hearing loss (onset at 6 years or more). We clearly indicated that genetic factors are the most common cause of hearing loss regardless of ethnic background. Saliva-based genetic testing is a useful tool for multi-center studies seeking to clarify the genetic causes of hearing loss in CI or EAS patients between countries separated by distance.
Pubmed PDF WebSerpil Demir Anı Parabakan Polat Cevahir Bulut Turay Selim Sermed Erbek a Department of Otolaryngology, Medical Faculty of Başkent University, Ankara, Turkeyb Department of Audiology, Gulhane Faculty of Health Sciences, University of Health Sciences, Ankara, Turkey
Publication date 21-10-2024
Systemic lu To evaluate the hearing and balance functions in SLE patients. Twenty-four SLE patients, 24 healthy controls underwent pure tone audiometry (0.125-16 k Hz), VNG, vestibular evoked myogenic potential (VEMP), and video head impulse test (vHIT). A statistically significant difference was determined between the control group and the SLE group at 0.125, 0.25, 0.5, 1.0, 6.0, 8.0, 10, 12, 14, and 16 k Hz frequencies. Sensorineural hearing loss was observed in 37.5% of the SLE group. The pursuit test was pathological at the rate of 25% in the SLE group. No response was obtained in six SLE patients in the oVEMP test and four SLE patients in the cVEMP test. The mean posterior SCC VOR gain values were 0.64 ± 0.2 in the SLE group. A significant difference was determined between the groups with respect to posterior SCC VOR gains. Our findings show that SLE disease may negatively affect the hearing system and the vestibular system as well. The current study is the first study to comprehensively evaluate SLE patients with VNG, VEMP, and vHIT tests.
Pubmed PDF WebMingbao Yang Bei Zhang Yafeng Guan Department of Otorhinolaryngology-Head and Neck Surgery, the University of Hong Kong-Shenzhen Hospital, Shenzhen, China
Publication date 21-10-2024
Facial paralysis patients with normal hearing often require ossicular chain dislocation throughout the entire process of facial nerve decompression surgery, and their hearing tends to be slightly impaired after surgery. There is not detailed explanation of hearing changes after facial nerve decompression with preserving intact ossicular chain. This study aimed to determine the efficacy and hearing outcomes of facial nerve decompression with preserving ossicular chain intact transmastoid supralabyrinthine recess pathway in Bell's palsy. A retrospective study comparing the pre- and post-operative facial nerve HB functional grades and hearing results of 12 patients with Bell's palsy who underwent facial nerve decompression. Preoperative and postoperative mean House-Brackmann (HB) scores respectively were 4.41 ± 0.67 and 1.58 ± 0.79 grades; The recovery rate to HB grade I, II was 100% or to grade III or lower was 83.3% (10/12). The pre- and post-operative mean PTAs (0.125, 0.25, 0.5, 1, 2, 4, 8KHz) were 19.1 ± 1.9 dB and 36.8 ± 4.1 dB; The pre- and postoperative low frequencies (0.125, 0.25KHz) were 18.5 ± 2.3 dB and 26 ± 3.8 dB; The pre- and postoperative speech frequencies (0.5, 1, 2KHz) mean PTAs were 18.5 ± 1.9 dB and 21.5 ± 2.9 dB; Comparison of pre- and post-operative hearing outcomes at all frequencies, low frequencies, and speech frequencies showed no statistically significant differences ( Subtotal facial nerve decompression with preserving ossicular chain intact transmastoid supralabyrinthine recess pathway does not cause the verbal frequency hearing loss of Bell's palsy, but it has high frequency sensorineural hearing loss, which tend to be unavoidable and independent of the skill of the surgical operator.
Pubmed PDF WebRasheed Omobolaji Alabi Alhadi Almangush Mohammed Elmusrati Ilmo Leivo Antti A. Mäkitie a Research Program in Systems Oncology, University of Helsinki, Helsinki, Finlandb Department of Industrial Digitalization, School of Technology and Innovations, University of Vaasa, Vaasa, Finlandc Department of Pathology, University of Helsinki, Helsinki, Finlandd Institute of Biomedicine, University of Turku, Pathology, Finlande Department of Otorhinolaryngology – Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finlandf Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden
Publication date 28-01-2024
The mortality rates of laryngeal squamous cell carcinoma cancer (LSCC) have not significantly decreased in the last decades.
Pubmed PDF WebQianqian Zhang Chen Zhang Jiani Chen Le Shi Yingqi Gao Yumin Zhou Fuying Cheng Dehui Wang Huan Wang Xicai Sun Li Hu a ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, Chinab High Altitude Rhinology Research Center of Eye &, ENT Hospital of Fudan University and People’s Hospital of Shigatse City, Chinac Department of Otolaryngology, People’s Hospital of Shigatse City, Shigatse, Chinad Refractory Chronic Sinusitis Clinical Center of Eye & ENT Hospital of Fudan University, Shanghai, China
Publication date 21-10-2024
The association between objective imaging findings and subjective symptoms remains undefined. To investigate the correlation between objective imaging findings and symptom severity in the overall chronic rhinosinusitis with nasal polyps (CRSwNP) population as well as its subendotypes according to the eosinophilic inflammation. Patients with CRSwNP undergoing endoscopic sinus surgery were included. All participants completed the Sino-Nasal Outcome Test (SNOT-22) questionnaire. The Lund-Mackay (LM) CT scores was also obtained. Spearman correlation analysis was performed to evaluate the correlation between CT scores and SNOT-22 scores. Forty-four non-eosinophilic CRSwNP(neCRSwNP) and 93 eosinophilic CRSwNP (eCRSwNP) patients were recruited. There was significant association between LM total score and nasal subdomain of SNOT-22 in the overall CRSwNP patients. The nasal symptom of SNOT-22 was significantly associated with maxillary, frontal, sphenoid, anterior drainage, and posterior drainage in all CRSwNP patients. In eCRSwNP and neCRSwNP patients, the sense of smell/taste was associated with sphenoid and posterior drainage. Thick nasal discharge was positively correlated with maxillary, frontal, and anterior drainage only in eCRSwNP patients. The high score of sphenoid and posterior drainage may suggest the occurrence of loss of sense of smell/taste, while high score of maxillary sinus may indicate suffering from thick nasal discharge in eCRSwNP patients.
Pubmed PDF WebShin-Ichi Usami Shin-ya Nishio Javier Gavilán Aanand Acharya Abdulrahman Hagr Luis Lassaletta Yongxin Li S. Sudha Maheshwari Mohan Kameswaran Thomas Parzefall Chris Raine Kristen Rak Anne Morgan Selleck Hinrich Staecker Timo Stöver Serafima Sugarova Vedat Topsakal Vincent Van Rompaey Griet Mertens Stefan Volkenstein Christiane Völter Wafaa Shehata-Dieler Mario E. Zernotti Paul Van de Heyning a Department of Hearing Implant Sciences, Shinshu University School of Medicine, Matsumoto, Japanb Department of Otolaryngology, La Paz University Hospital, Madrid, Spainc Fiona Stanley Fremantle Hospitals Group, Perth, Australiad Division of Surgery, Medical School, The University of Western Australia, Perth, Australiae King Abdullah Ear Specialist Center, College of Medicine, King Saud University, Riyadh, Saudi Arabiaf IdiPAZ Research Institute, Madrid, Spaing Biomedical Research Networking Centre On Rare Diseases (CIBERER), Institute of Health Carlos III (CIBERER-U761), Madrid, Spainh Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, Chinai Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Beijing, Chinaj Madras ENT Research Foundation (P) Ltd Chennai, Chennai, Indiak Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austrial Yorkshire Auditory Implant Service, Bradford Royal Infirmary, Bradford, UKm Department of Otorhinolaryngology, Head & Neck Surgery, Comprehensive Hearing Center, University of Würzburg, Würzburg, Germanyn Department of Otolaryngology/Head & Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAo Kansas University Center for Hearing and Balance Disorders, Kansas City, KA, USAp Department of Otolaryngology, Head and Neck Surgery, University Hospital Frankfurt, Frankfurt am Main, Germanyq St. Petersburg ENT and Speech Research Institute, St. Petersburg, Russiar Department of Otolaryngology and Head & Neck Surgery, Vrije Universiteit Brussel, University Hospital UZ Brussel, Brussels Health Campus, Brussels, Belgiums Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, Edegem, Belgiumt Department of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgiumu Department of Otorhinolaryngology, Head & Neck Surgery, Johannes Wesling Klinikum Minden, Ruhr-University of Bochum, Minden, Germanyv Department of Otorhinolaryngology, Head and Neck Surgery, St. Elisabeth Hospital, University of Bochum, Bochum, Germanyw Catholic University of Córdoba and National University of Córdoba, Córdoba, Argentina
Publication date 25-10-2024
In cases of congenital sensorineural hearing loss, testing for genetic etiologies and congenital cytomegalovirus (cCMV) infection have become common practice. The purpose of this study is to determine which specific testing methodologies should be used and when. We surveyed 20 practicing otolaryngologists across eighteen institutions in thirteen countries about their approach to cCMV, GJB2, and wider genetic testing. We found 90% of respondents employ all three tests, either in routine or special cases. cCMV testing is widely used, with 95% of respondents incorporating it into their clinical practice. A common approach is to perform cCMV and
Pubmed PDF WebBurak Hazır Zeliha Berfu Kastal Eray Uzunoğlu a Department of Otorhinolaryngology/Head and Neck Surgery, Ankara City Hospital, Ankara, Turkeyb Department of Otorhinolaryngology/Head and Neck Surgery, Izmir Ekol Hospital, İzmir, Turkey
Publication date 26-10-2024
The presence of This study aimed to determine the frequency of post-tonsillectomy hemorrhage (PTH), the presence of The cases who underwent tonsillectomy at a single center were included in the study. Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), systemic immune inflammation index (SII) and systemic inflammation response index (SIRI) values were calculated from the complete blood count test. The presence of A total of 1137 patients were included in the study. According to the data in our study, NLR and SIRI values were elevated in subjects with
Pubmed PDF WebNing Zhou Dan Su Junjie Ma Department of Otolaryngology Head and Neck Surgery, The First Hospital of Anhui University of Science & Technology, Huainan, China
Publication date 28-10-2024
Endoscopic sphenopalatine artery cauterization (ESPAC) has become an important method to manage posterior epistaxis. To investigate the application of plasma knife and lateral nasal wall incision in ESPAC in the treatment of posterior epistaxis. A retrospective study of 32 cases who underwent ESPAC for epistaxis was conducted. A vertical incision was made on the lateral nasal well to expose the sphenopalatine artery (SPA). The main branches of SPA were cauterized with a plasma knife or bipolar coagulation forceps. Cases were divided into plasma knife group (group PK) and bipolar group (group BP). The re-bleeding rates, operation time and the incidence of serious complication were compared between the two groups. ESPAC was successfully completed Lateral nasal well incision without maxillary antrostomy is feasible for ESPAC. The application of a plasma knife may help to shorten the operation time.
Pubmed PDF WebEray Uzunoğlu Muhittin Akalın Zübeyde Nur Özkurt Zeynep Arzu Yegin Recep Karamert a Department of Otorhinolaryngology/Head and Neck Surgery, Izmir Ekol Hospital, Ankara, Turkeyb Department of Otorhinolaryngology, Gazi University Hospital, Ankara, Turkeyc Department of Hematology, Gazi University Hospital, Ankara, Turkey
Publication date 29-10-2024
Hematopoietic stem cell transplantation (HSCT) is a critical treatment for various hematologic malignancies but can lead to complications, including ototoxicity. This study aims to explore the relationship between patient-specific factors and ototoxicity in adult HSCT patients. We conducted a retrospective analysis of 129 adult patients who underwent HSCT between 2003 and 2020. Age, gender, transplant indications, conditioning regimens, and pre- and post-transplant audiometry thresholds data were collected from patient files. A hearing loss of 10 decibels or more at two consecutive frequencies or a hearing loss of 20 decibels or more at a single frequency was considered as significant hearing loss (SHL). Statistical analyses were performed to describe factors associated with SHL. SHL occurred in 16.3% of patients. Older age was significantly associated with an increased risk of SHL ( Age and pre-existing hearing levels are significant predictors of ototoxicity post-HSCT. Careful management and monitoring are essential to prevent and address hearing loss in HSCT patients to improve hearing-related quality of life.
Pubmed PDF WebJenny Knubb Henrik M. Sjöblom Ella Ikonen Miika Suomela Jaakko M. Piitulainen a Department of Otorhinolaryngology, Faculty of Medicine, University of Turku, Turku, Finlandb Division of Surgery and Cancer Diseases, Department of Otorhinolaryngology–Head and Neck Surgery, Turku University Hospital, Turku, Finlandc Department of Clinical Neurophysiology, Turku University Hospital, Turku, Finland
Publication date 01-11-2024
Tonsillectomy is an effective treatment option for obstructive sleep apnoea in selected adult patients, but there has been a lack of long-term follow-up data. To analyse the long-term outcomes of extracapsular tonsillectomy in the treatment of obstructive sleep apnoea in adults, with the longest follow-up periods to date. We recruited adults who had undergone extracapsular tonsillectomy because of obstructive sleep apnoea between 2004 and 2018 in the Hospital District of Southwest Finland. A new home sleep study, questionnaires, and a structured phone interview were conducted on these patients 4-17 years after surgical treatment. The primary outcome was the change in the apnoea-hypopnoea index. The mean apnoea-hypopnoea index was reduced from 27.1 preoperatively to 14.1 after the long-term follow-up (mean 12 years), and the mean Epworth Sleepiness Scale score decreased from 9.2 to 4.6. The long-term surgical success rate was 38.5%. Four out of five patients would choose the surgery again according to the phone interview. This study supports the notion that extracapsular tonsillectomy alone can be considered as a surgical treatment option for selected adults with obstructive sleep apnoea and tonsillar hypertrophy. For most of the patients, the obstructive sleep apnoea is alleviated.
Pubmed PDF WebBingtong Lin Yuan Liu Dezhi Deng Genquan Huang Juan Qu Junjie Xu Jin Hu Baoxiang Wang a Zhejiang Chinese Medical University, Hangzhou, Chinab Department of Neurology, Affiliated Hospital of Jiaxing University, The First Hospital of Jiaxing, Jiaxing, China
Publication date 02-11-2024
Horizontal semicircular canal benign paroxysmal positional vertigo(HSC-BPPV) is the second most common type of BPPV. It is difficult to diagnose and treat, which has a serious impact on the prognosis of patients. To study the clinical features of HSC-BPPV and the influencing factors of residual dizziness (RD). The clinical data of 358 patients with BPPV were retrospectively collected. The differences between HSC-BPPV and posterior semicircular canal benign paroxysmal positional vertigo (PSC-BPPV) were compared, and the influencing factors of RD after HSC-BPPV repositioning were analyzed. ① Compared with PSC-BPPV, HSC-BPPV had a lower success rate of first repositioning (64.7 The diagnosis and treatment of HSC-BPPV is difficult, and RD is prone to occur. Clinicians need to strengthen the training of HSC-BPPV diagnosis and treatment to reduce the occurrence and progression of RD.
Pubmed PDF WebKasper Gydesen Rasmus Bülow Kasper Aanaes Anne Fog Lomholt Tina Agander Christian von Buchwald Sannia Sjöstedt a Department of Otorhinolaryngology, Head & Neck Surgery and Audiology, Rigshospitalet and Faculty of Health and Medical Sciences, University of Copenhagen, Denmarkb Department of Pathology, Rigshospitalet and Faculty of Health and Medical Sciences, University of Copenhagen, Denmarkc Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Denmark
Publication date 05-11-2024
Inverted papilloma is a benign epithelial tumour located in the sinonasal tract with a high recurrence rate and a potential of malignant transformation. From 2017, patients with IP were included in our fast-track regime similar to head and neck cancer patients, including follow-up at 2, 6, 12, 18 and 24 months after surgery, then yearly for a total of 5 years. This study aims to compare the recurrence rate and malignant transformation of patients with IP treated at a university centre following the implementation of a fast-track regime including a close follow-up. A retrospective study was performed on all patients with IP diagnosed between 2018 and 2022. The study included 125 patients, all surgically treated for IP. Eight patients (6%) also presented with SCC at the time of diagnosis. The recurrence rate of benign IP was 17%. Most tumours originated in the maxillary sinus (48/117, 41%). No cases of metachronous cancer were seen during the follow-up. The majority of recurrences (90%) occurred within the first 2 years after treatment. No cases of malignant transformation were seen in the follow-up period. The rigorous follow-up program potentially contributed to the detection of recurrence before malignant transformation.
Pubmed PDF WebWeiwei Han Qinfeng Wu Yunqin Wu Xiaoxiong Lu Lulu Li Kewang Zhou Weinv Fan a Department of Rehabilitation, Ningbo No.2 Hospital, Ningbo, P.R. Chinab Department of Neurology, The third people’s hospital health care group of Cixi, Ningbo, P.R. Chinac Department of Neurology, Ningbo No.2 Hospital, Ningbo, P.R. China
Publication date 13-11-2024
Otolin-1 and otoconin-90, the main otoconia matrix protein, can pass through the labyrinth-blood barrier and are detectable in the peripheral blood. Previous studies have shown that serum levels of these proteins well reflect otolith status, but none of concerning Meniere's disease (MD). This study aimed to evaluate the serum levels of otolin-1 and otoconin-90 in patients with MD. Patients with MD confirmed during an acute episode, and age- and sex-matched controls were recruited. Their demographic and clinical data were recorded. The serum levels of otolin-1 and otoconin-90 were measured and compared. A total of 33 patients with MD and 176 healthy controls were recruited. In patients with MD, the median otolin-1 level was 284.96 pg/mL (interquartile range [IQR] 208.65-331.49 pg/mL) and the median otoconin-90 level was 60.50 ng/mL (IQR 40.61-85.62 ng/mL), which were significantly higher than those in the control group ( Serum levels of otolin-1 and otoconin-90 may serve as biomarkers of otolith lesions in patients with MD.
Pubmed PDF WebStefania Goncalves Torin Thielhelm Devon Pawley Esperanza Bas Emre Dikici Sapna K. Deo Christine T. Dinh Sylvia Daunert Fred Telischi a Department of Otolaryngology – Head and Neck Surgery, University of Miami Ear Institute, University of Miami, Miller School of Medicine, Miami, FL, USAb Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, Miami, FL, USAc Dr. JT Macdonal Foundation Biomedial Nanotechnology Institute, University of Miami, Miami, FL, USAd Department of Research Pharmacy, Sylvester Comprehensive Cancer Center, Miami, FL, USAe University of Miami Clinical and Translational Science Institute, University of Miami, Miller School of Medicine, Miami, FL, USA
Publication date 13-11-2024
The delivery of drugs into the inner ear is a challenging field of study due to the complex cochlear anatomy and physiology. The creation of an intracochlear device that allows for short- and long-term intracochlear delivery of the drugs with a minimal invasive technology is needed to prevent or treat conditions that can potentially prevent the development of permanent hearing loss. This study intends to test the efficacy of DXM-infused PLGA microneedles created in our laboratory in an Twenty-four male Norway Brown rats were randomized into four groups, three of which groups received an intratympanic injection of ethacrynic acid and kanamycin. Two of these groups underwent the placement of an intracochlear microneedle blended or not with dexamethasone, and two groups underwent implantation of a plain microneedle, one of without prior exposure to the ototoxic agent to confirm Our intracochlear device demonstrated biocompatibility and produced no hearing changes after its implantation in the control group. Inserted DXM-blended microneedles prevented hearing deterioration in those animals exposed to an ototoxic environment.
Pubmed PDF WebOlof Nilsson Mathias von Beckerath Johan Knutsson Fredrik J. Landström a Department of Otolaryngology, Örebro University Hospital, Örebro, Swedenb School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Swedenc Department of Head and Neck Surgery, Medical Unit Head Neck Lung and Skin Cancer, Karolinska University Hospital, Stockholm, Swedend Department of Clinical Sciences Intervention and Technology, Division of Ear Nose and Throat Diseases, Karolinska Institute, Stockholm, Swedene Department of Otolaryngology, Vasteras Hospital, Vasteras, Swedenf Region Vastmanland – Uppsala University, Centre for Clinical Research, Vastmanland Hospital, Vasteras, Sweden
Publication date 13-11-2024
In oral cancers, tumour borders are typically defined by white light (WL). Narrow-band imaging (NBI) is an optical endoscopic technique commonly used for the larynx and for cancers of unknown primary. However, evidence for using NBI in oral cancers is insufficient. We investigated whether NBI is a better predictor of the true mucosal tumour borders than WL in oral cancers. Additionally, we examined the agreement between NBI-based Takano intrapapillary capillary loop classifications and pathology reports. In this prospective study, the tumour borders were assessed by both NBI and WL at the time of surgical resection and then compared. Pathology reports of the examined areas were used as gold standard. Forty-nine participants were included. After exclusion of 15 patients due to missing data, 34 were included in analyses. In 26.5% of the assessments, the tumour borders defined by NBI were outside the borders defined by WL. However, 55.5% of these were false-positives. The delineation of mucosal tumour borders in oral cancers by NBI was not better than that by WL in this study. Several methodological challenges may have influenced the findings of this study, similar to the limitations reported in previous studies.
Pubmed PDF WebAya Katsura Ryoukichi Ikeda Masato Suzuki Iori Kusaka Shinsuke Kaneshiro Toshihiko Abe Shigeru Kuwashima Katsunori Katagiri Jun Suzuki Kiyoto Shiga a Department of Otolaryngology and Head and Neck Surgery, Iwate Medical University School of Medicine, Yahaba, Japanb Department of Otolaryngology and Head and Neck Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
Publication date 15-11-2024
Deep neck infections (DNIs) in the cervical fascial planes can cause severe complications such as airway obstruction, mediastinitis, and sepsis. This study examines cervical abscess development, its relationship with postoperative swallowing function, and hospital stay duration. A retrospective case series of 55 DNI patients was divided by hospital stay (<30 days: Group A, ≥30 days: Group B) and swallowing recovery (<6 days: Group C, ≥6 days: Group D). Swallowing was assessed using FOIS; abscesses were categorized Longer hospital stays (Group B) were associated with tracheostomy ( Dysphagia is associated with abscesses in the anterior cervical and retropharyngeal spaces and higher
Pubmed PDF WebAntoine Dubray-Vautrin Benjamin Vérillaud Philippe Herman Romain Kania a Department of Oto-Rhino-Laryngology, Head & Neck Surgery, Center of Neurosensorial-Head&Neck Diseases, Lariboisière Hospital, University of Paris Cité, Assistance Publique des Hôpitaux de Paris & UMR 1141 Center for the Developing Brain, Paris Biobank BB-0033-00064, Platform of Biopathology and Innovative Technologies for Health, Paris, Franceb Department of Oto-Rhino-Laryngology, Head & Neck Surgery, Institut Curie, Paris, France
Publication date 12-02-2024
Squamous cell carcinoma (SCC) of the temporal bone (TB) is a rare pathology originating from the external auditory canal (EAC). Surgery remains the gold standard to achieve local control.
Aims/Objectives:The aim of this study was to evaluate overall survival (OS) and disease-free survival (DFS) after surgery of the SCC of EAC.
A retrospective chart review in a tertiary referral center included 26 patients: 23 were operated with lateral temporal bone resection (LTBR,
Adjuvant radiotherapy was performed in 91.3% (
En bloc surgical resection with free margins, coupled with postoperative radiotherapy, provides optimal local control. For stage IV tumors, where complete margins are achievable, ETBR is recommended to enhance local control.