Burak Hazır Zeliha Berfu Kastal Eray Uzunoğlu a Department of Otorhinolaryngology/Head and Neck Surgery, Ankara City Hospital, Ankara, Turkeyb Department of Otorhinolaryngology/Head and Neck Surgery, Izmir Ekol Hospital, İzmir, Turkey
Publicatie 26-10-2024
The presence of This study aimed to determine the frequency of post-tonsillectomy hemorrhage (PTH), the presence of The cases who underwent tonsillectomy at a single center were included in the study. Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), systemic immune inflammation index (SII) and systemic inflammation response index (SIRI) values were calculated from the complete blood count test. The presence of A total of 1137 patients were included in the study. According to the data in our study, NLR and SIRI values were elevated in subjects with
Pubmed PDF WebEray Uzunoğlu Muhittin Akalın Zübeyde Nur Özkurt Zeynep Arzu Yegin Recep Karamert a Department of Otorhinolaryngology/Head and Neck Surgery, Izmir Ekol Hospital, Ankara, Turkeyb Department of Otorhinolaryngology, Gazi University Hospital, Ankara, Turkeyc Department of Hematology, Gazi University Hospital, Ankara, Turkey
Publicatie 29-10-2024
Hematopoietic stem cell transplantation (HSCT) is a critical treatment for various hematologic malignancies but can lead to complications, including ototoxicity. This study aims to explore the relationship between patient-specific factors and ototoxicity in adult HSCT patients. We conducted a retrospective analysis of 129 adult patients who underwent HSCT between 2003 and 2020. Age, gender, transplant indications, conditioning regimens, and pre- and post-transplant audiometry thresholds data were collected from patient files. A hearing loss of 10 decibels or more at two consecutive frequencies or a hearing loss of 20 decibels or more at a single frequency was considered as significant hearing loss (SHL). Statistical analyses were performed to describe factors associated with SHL. SHL occurred in 16.3% of patients. Older age was significantly associated with an increased risk of SHL ( Age and pre-existing hearing levels are significant predictors of ototoxicity post-HSCT. Careful management and monitoring are essential to prevent and address hearing loss in HSCT patients to improve hearing-related quality of life.
Pubmed PDF WebStefania Goncalves Torin Thielhelm Devon Pawley Esperanza Bas Emre Dikici Sapna K. Deo Christine T. Dinh Sylvia Daunert Fred Telischi a Department of Otolaryngology – Head and Neck Surgery, University of Miami Ear Institute, University of Miami, Miller School of Medicine, Miami, FL, USAb Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, Miami, FL, USAc Dr. JT Macdonal Foundation Biomedial Nanotechnology Institute, University of Miami, Miami, FL, USAd Department of Research Pharmacy, Sylvester Comprehensive Cancer Center, Miami, FL, USAe University of Miami Clinical and Translational Science Institute, University of Miami, Miller School of Medicine, Miami, FL, USA
Publicatie 13-11-2024
The delivery of drugs into the inner ear is a challenging field of study due to the complex cochlear anatomy and physiology. The creation of an intracochlear device that allows for short- and long-term intracochlear delivery of the drugs with a minimal invasive technology is needed to prevent or treat conditions that can potentially prevent the development of permanent hearing loss. This study intends to test the efficacy of DXM-infused PLGA microneedles created in our laboratory in an Twenty-four male Norway Brown rats were randomized into four groups, three of which groups received an intratympanic injection of ethacrynic acid and kanamycin. Two of these groups underwent the placement of an intracochlear microneedle blended or not with dexamethasone, and two groups underwent implantation of a plain microneedle, one of without prior exposure to the ototoxic agent to confirm Our intracochlear device demonstrated biocompatibility and produced no hearing changes after its implantation in the control group. Inserted DXM-blended microneedles prevented hearing deterioration in those animals exposed to an ototoxic environment.
Pubmed PDF WebShin-Ichi Usami Shin-ya Nishio Javier Gavilán Aanand Acharya Abdulrahman Hagr Luis Lassaletta Yongxin Li S. Sudha Maheshwari Mohan Kameswaran Thomas Parzefall Chris Raine Kristen Rak Anne Morgan Selleck Hinrich Staecker Timo Stöver Serafima Sugarova Vedat Topsakal Vincent Van Rompaey Griet Mertens Stefan Volkenstein Christiane Völter Wafaa Shehata-Dieler Mario E. Zernotti Paul Van de Heyning a Department of Hearing Implant Sciences, Shinshu University School of Medicine, Matsumoto, Japanb Department of Otolaryngology, La Paz University Hospital, Madrid, Spainc Fiona Stanley Fremantle Hospitals Group, Perth, Australiad Division of Surgery, Medical School, The University of Western Australia, Perth, Australiae King Abdullah Ear Specialist Center, College of Medicine, King Saud University, Riyadh, Saudi Arabiaf IdiPAZ Research Institute, Madrid, Spaing Biomedical Research Networking Centre On Rare Diseases (CIBERER), Institute of Health Carlos III (CIBERER-U761), Madrid, Spainh Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, Chinai Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Beijing, Chinaj Madras ENT Research Foundation (P) Ltd Chennai, Chennai, Indiak Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austrial Yorkshire Auditory Implant Service, Bradford Royal Infirmary, Bradford, UKm Department of Otorhinolaryngology, Head & Neck Surgery, Comprehensive Hearing Center, University of Würzburg, Würzburg, Germanyn Department of Otolaryngology/Head & Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAo Kansas University Center for Hearing and Balance Disorders, Kansas City, KA, USAp Department of Otolaryngology, Head and Neck Surgery, University Hospital Frankfurt, Frankfurt am Main, Germanyq St. Petersburg ENT and Speech Research Institute, St. Petersburg, Russiar Department of Otolaryngology and Head & Neck Surgery, Vrije Universiteit Brussel, University Hospital UZ Brussel, Brussels Health Campus, Brussels, Belgiums Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, Edegem, Belgiumt Department of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgiumu Department of Otorhinolaryngology, Head & Neck Surgery, Johannes Wesling Klinikum Minden, Ruhr-University of Bochum, Minden, Germanyv Department of Otorhinolaryngology, Head and Neck Surgery, St. Elisabeth Hospital, University of Bochum, Bochum, Germanyw Catholic University of Córdoba and National University of Córdoba, Córdoba, Argentina
Publicatie 25-10-2024
In cases of congenital sensorineural hearing loss, testing for genetic etiologies and congenital cytomegalovirus (cCMV) infection have become common practice. The purpose of this study is to determine which specific testing methodologies should be used and when. We surveyed 20 practicing otolaryngologists across eighteen institutions in thirteen countries about their approach to cCMV, GJB2, and wider genetic testing. We found 90% of respondents employ all three tests, either in routine or special cases. cCMV testing is widely used, with 95% of respondents incorporating it into their clinical practice. A common approach is to perform cCMV and
Pubmed PDF WebBingtong Lin Yuan Liu Dezhi Deng Genquan Huang Juan Qu Junjie Xu Jin Hu Baoxiang Wang a Zhejiang Chinese Medical University, Hangzhou, Chinab Department of Neurology, Affiliated Hospital of Jiaxing University, The First Hospital of Jiaxing, Jiaxing, China
Publicatie 02-11-2024
Horizontal semicircular canal benign paroxysmal positional vertigo(HSC-BPPV) is the second most common type of BPPV. It is difficult to diagnose and treat, which has a serious impact on the prognosis of patients. To study the clinical features of HSC-BPPV and the influencing factors of residual dizziness (RD). The clinical data of 358 patients with BPPV were retrospectively collected. The differences between HSC-BPPV and posterior semicircular canal benign paroxysmal positional vertigo (PSC-BPPV) were compared, and the influencing factors of RD after HSC-BPPV repositioning were analyzed. ① Compared with PSC-BPPV, HSC-BPPV had a lower success rate of first repositioning (64.7 The diagnosis and treatment of HSC-BPPV is difficult, and RD is prone to occur. Clinicians need to strengthen the training of HSC-BPPV diagnosis and treatment to reduce the occurrence and progression of RD.
Pubmed PDF WebNing Zhou Dan Su Junjie Ma Department of Otolaryngology Head and Neck Surgery, The First Hospital of Anhui University of Science & Technology, Huainan, China
Publicatie 28-10-2024
Endoscopic sphenopalatine artery cauterization (ESPAC) has become an important method to manage posterior epistaxis. To investigate the application of plasma knife and lateral nasal wall incision in ESPAC in the treatment of posterior epistaxis. A retrospective study of 32 cases who underwent ESPAC for epistaxis was conducted. A vertical incision was made on the lateral nasal well to expose the sphenopalatine artery (SPA). The main branches of SPA were cauterized with a plasma knife or bipolar coagulation forceps. Cases were divided into plasma knife group (group PK) and bipolar group (group BP). The re-bleeding rates, operation time and the incidence of serious complication were compared between the two groups. ESPAC was successfully completed Lateral nasal well incision without maxillary antrostomy is feasible for ESPAC. The application of a plasma knife may help to shorten the operation time.
Pubmed PDF WebOlof Nilsson Mathias von Beckerath Johan Knutsson Fredrik J. Landström a Department of Otolaryngology, Örebro University Hospital, Örebro, Swedenb School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Swedenc Department of Head and Neck Surgery, Medical Unit Head Neck Lung and Skin Cancer, Karolinska University Hospital, Stockholm, Swedend Department of Clinical Sciences Intervention and Technology, Division of Ear Nose and Throat Diseases, Karolinska Institute, Stockholm, Swedene Department of Otolaryngology, Vasteras Hospital, Vasteras, Swedenf Region Vastmanland – Uppsala University, Centre for Clinical Research, Vastmanland Hospital, Vasteras, Sweden
Publicatie 13-11-2024
In oral cancers, tumour borders are typically defined by white light (WL). Narrow-band imaging (NBI) is an optical endoscopic technique commonly used for the larynx and for cancers of unknown primary. However, evidence for using NBI in oral cancers is insufficient. We investigated whether NBI is a better predictor of the true mucosal tumour borders than WL in oral cancers. Additionally, we examined the agreement between NBI-based Takano intrapapillary capillary loop classifications and pathology reports. In this prospective study, the tumour borders were assessed by both NBI and WL at the time of surgical resection and then compared. Pathology reports of the examined areas were used as gold standard. Forty-nine participants were included. After exclusion of 15 patients due to missing data, 34 were included in analyses. In 26.5% of the assessments, the tumour borders defined by NBI were outside the borders defined by WL. However, 55.5% of these were false-positives. The delineation of mucosal tumour borders in oral cancers by NBI was not better than that by WL in this study. Several methodological challenges may have influenced the findings of this study, similar to the limitations reported in previous studies.
Pubmed PDF WebJenny Knubb Henrik M. Sjöblom Ella Ikonen Miika Suomela Jaakko M. Piitulainen a Department of Otorhinolaryngology, Faculty of Medicine, University of Turku, Turku, Finlandb Division of Surgery and Cancer Diseases, Department of Otorhinolaryngology–Head and Neck Surgery, Turku University Hospital, Turku, Finlandc Department of Clinical Neurophysiology, Turku University Hospital, Turku, Finland
Publicatie 01-11-2024
Tonsillectomy is an effective treatment option for obstructive sleep apnoea in selected adult patients, but there has been a lack of long-term follow-up data. To analyse the long-term outcomes of extracapsular tonsillectomy in the treatment of obstructive sleep apnoea in adults, with the longest follow-up periods to date. We recruited adults who had undergone extracapsular tonsillectomy because of obstructive sleep apnoea between 2004 and 2018 in the Hospital District of Southwest Finland. A new home sleep study, questionnaires, and a structured phone interview were conducted on these patients 4-17 years after surgical treatment. The primary outcome was the change in the apnoea-hypopnoea index. The mean apnoea-hypopnoea index was reduced from 27.1 preoperatively to 14.1 after the long-term follow-up (mean 12 years), and the mean Epworth Sleepiness Scale score decreased from 9.2 to 4.6. The long-term surgical success rate was 38.5%. Four out of five patients would choose the surgery again according to the phone interview. This study supports the notion that extracapsular tonsillectomy alone can be considered as a surgical treatment option for selected adults with obstructive sleep apnoea and tonsillar hypertrophy. For most of the patients, the obstructive sleep apnoea is alleviated.
Pubmed PDF WebWeiwei Han Qinfeng Wu Yunqin Wu Xiaoxiong Lu Lulu Li Kewang Zhou Weinv Fan a Department of Rehabilitation, Ningbo No.2 Hospital, Ningbo, P.R. Chinab Department of Neurology, The third people’s hospital health care group of Cixi, Ningbo, P.R. Chinac Department of Neurology, Ningbo No.2 Hospital, Ningbo, P.R. China
Publicatie 13-11-2024
Otolin-1 and otoconin-90, the main otoconia matrix protein, can pass through the labyrinth-blood barrier and are detectable in the peripheral blood. Previous studies have shown that serum levels of these proteins well reflect otolith status, but none of concerning Meniere's disease (MD). This study aimed to evaluate the serum levels of otolin-1 and otoconin-90 in patients with MD. Patients with MD confirmed during an acute episode, and age- and sex-matched controls were recruited. Their demographic and clinical data were recorded. The serum levels of otolin-1 and otoconin-90 were measured and compared. A total of 33 patients with MD and 176 healthy controls were recruited. In patients with MD, the median otolin-1 level was 284.96 pg/mL (interquartile range [IQR] 208.65-331.49 pg/mL) and the median otoconin-90 level was 60.50 ng/mL (IQR 40.61-85.62 ng/mL), which were significantly higher than those in the control group ( Serum levels of otolin-1 and otoconin-90 may serve as biomarkers of otolith lesions in patients with MD.
Pubmed PDF WebGiannicola Iannella Annalisa Pace Antonio Greco Armando De Virgilio Lodovica Gatti Antonino Maniaci Jerome R. Lechien Rémi Hervochon Ali Faramarzi Quentin Mat Maryana Cherkes Matthias Koiner-Graupp Paolo Boscolo-Rizzo Luigi Angelo Vaira Giuseppe Magliulo a Department of ‘Organi di Senso’, University “Sapienza”, Rome, Italyb Department of Otolaryngology, Kore University, Enna, Italyc EpiCURA Hospital & University of Mons, Mons, Belgiumd Service d’ORL et Chirurgie Cervico-Faciale, Pitié-Salpêtrière Hospital, APHP (Greater Paris University Hospitals), Parise Otolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iranf Department of Otorhinolaryngology, C.H.U. Charleroi, Charleroi, Belgiumg Department of Otolaryngology and Head & Neck Surgery Medical, University of Graz, Austriah Department of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italyi Maxillofacial Surgery Operative Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy
Publicatie 25-11-2024
endoscopic ear surgery in patients Chronic Otitis Media(COM) media with eardrum atelectasis. to compare the postoperative outcomes and audiological results of the endoscopic approach versus the microscopic approach for treatment of COM media with eardrum atelectasis, using a randomized prospective model. Sixty patients were consecutively enrolled in the study and randomized into two groups: Group A 32 patients underwent canal wall up tympanoplasty (CWA); Group B 28 patients underwent tympanoplasty with an exclusive trans-meatal endoscopic approach. Audiological results and preoperative, intraoperative and postoperative outcomes were evaluated. No statistical difference emerged between distribution of middle ear atelectasis patients grade 3 and 4 between the two surgical groups ( Endoscopic ear surgery could be a suitable approach for treating COM media with eardrum atelectasis with similar results compared with the Microscopic surgery.
Pubmed PDF WebPedro Marques Gomes Diogo Cunha Cabral Joana Barreto André Alves Carção Delfim Duarte José Ferreira Penêda Department of Otorhinolaryngology, Hospital Pedro Hispano, Unidade Local de Saúde de Matosinhos, Porto, Portugal
Publicatie 15-11-2024
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a medical condition characterized by persistent inflammation of the nasal mucosa and sinuses, accompanied by the presence of nasal polyps. When medical treatments prove ineffective, endoscopic sinus surgery (ESS) is recommended, yielding variable outcomes and recurrence rates ranging from 5% to 60%. The primary objectives of this study were to evaluate the outcomes of ESS and to identify independent predictors of recurrence and revision surgery. Retrospective cross-sectional study, focusing on patients diagnosed with CRSwNP who underwent ESS with a minimum follow-up period of 60 months. Various variables were collected. Multivariate and regression analyses were employed to assess the predictors associated with both recurrence and revision surgery. The study analyzed 130 patients. The 5-year recurrence rate was 35.4%, and 17.7% of patients required revision surgery. These variables included asthma ( Asthma, frontal sinus involvement, increased eosinophilia in peripheral blood, and a higher score on the LM system and NPS are poor prognostic factors in CRSwNP.
Pubmed PDF WebAya Katsura Ryoukichi Ikeda Masato Suzuki Iori Kusaka Shinsuke Kaneshiro Toshihiko Abe Shigeru Kuwashima Katsunori Katagiri Jun Suzuki Kiyoto Shiga a Department of Otolaryngology and Head and Neck Surgery, Iwate Medical University School of Medicine, Yahaba, Japanb Department of Otolaryngology and Head and Neck Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
Publicatie 15-11-2024
Deep neck infections (DNIs) in the cervical fascial planes can cause severe complications such as airway obstruction, mediastinitis, and sepsis. This study examines cervical abscess development, its relationship with postoperative swallowing function, and hospital stay duration. A retrospective case series of 55 DNI patients was divided by hospital stay (<30 days: Group A, ≥30 days: Group B) and swallowing recovery (<6 days: Group C, ≥6 days: Group D). Swallowing was assessed using FOIS; abscesses were categorized Longer hospital stays (Group B) were associated with tracheostomy ( Dysphagia is associated with abscesses in the anterior cervical and retropharyngeal spaces and higher
Pubmed PDF WebSerpil Demir Alper Köycü Selim S. Erbek Department of Otolaryngology, Medical Faculty of Başkent University 06490 Bahçelievler, Ankara, Turkey
Publicatie 27-11-2024
Because the inner ear requires high-energy metabolism and because of the iron content of some cochlear enzymes, iron deficiency-related hypoxia can affect hearing and the balance system. To evaluate the hearing and balance functions in adults with iron deficiency (ID) and iron deficiency anemia (IDA). 22 ID patients, 22 IDA patients and 22 healthy controls underwent pure tone audiometry (0.125-16 kHz), VNG, VEMP, and vHIT. Significant differences were observed in the hearing thresholds of the IDA group at frequencies ranging from 0.125 kHz to 14 kHz, as well as in the ID group at frequencies of 2.0 kHz, 4.0 kHz, and 6.0 kHz. The pursuit test was pathological at the rate of 40.9% in the IDA group. The oVEMP test showed prolonged latency values in both ID and IDA groups. IDA group had lower p1-n1 amplitude than the control group in the oVEMP and cVEMP tests. A significant difference was determined between the groups concerning anterior SCC VOR gains. The hypoxia caused by anemia might negatively impact hearing and vestibular functions. The current study is the first study to comprehensively evaluate anemia patients with VNG, VEMP, and vHIT tests.
Pubmed PDF WebKasper Gydesen Rasmus Bülow Kasper Aanaes Anne Fog Lomholt Tina Agander Christian von Buchwald Sannia Sjöstedt a Department of Otorhinolaryngology, Head & Neck Surgery and Audiology, Rigshospitalet and Faculty of Health and Medical Sciences, University of Copenhagen, Denmarkb Department of Pathology, Rigshospitalet and Faculty of Health and Medical Sciences, University of Copenhagen, Denmarkc Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Denmark
Publicatie 05-11-2024
Inverted papilloma is a benign epithelial tumour located in the sinonasal tract with a high recurrence rate and a potential of malignant transformation. From 2017, patients with IP were included in our fast-track regime similar to head and neck cancer patients, including follow-up at 2, 6, 12, 18 and 24 months after surgery, then yearly for a total of 5 years. This study aims to compare the recurrence rate and malignant transformation of patients with IP treated at a university centre following the implementation of a fast-track regime including a close follow-up. A retrospective study was performed on all patients with IP diagnosed between 2018 and 2022. The study included 125 patients, all surgically treated for IP. Eight patients (6%) also presented with SCC at the time of diagnosis. The recurrence rate of benign IP was 17%. Most tumours originated in the maxillary sinus (48/117, 41%). No cases of metachronous cancer were seen during the follow-up. The majority of recurrences (90%) occurred within the first 2 years after treatment. No cases of malignant transformation were seen in the follow-up period. The rigorous follow-up program potentially contributed to the detection of recurrence before malignant transformation.
Pubmed PDF WebQianqian Zhang Chen Zhang Jiani Chen Le Shi Yingqi Gao Yumin Zhou Fuying Cheng Dehui Wang Huan Wang Xicai Sun Li Hu a ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, Chinab High Altitude Rhinology Research Center of Eye &, ENT Hospital of Fudan University and People’s Hospital of Shigatse City, Chinac Department of Otolaryngology, People’s Hospital of Shigatse City, Shigatse, Chinad Refractory Chronic Sinusitis Clinical Center of Eye & ENT Hospital of Fudan University, Shanghai, China
Publicatie 21-10-2024
The association between objective imaging findings and subjective symptoms remains undefined. To investigate the correlation between objective imaging findings and symptom severity in the overall chronic rhinosinusitis with nasal polyps (CRSwNP) population as well as its subendotypes according to the eosinophilic inflammation. Patients with CRSwNP undergoing endoscopic sinus surgery were included. All participants completed the Sino-Nasal Outcome Test (SNOT-22) questionnaire. The Lund-Mackay (LM) CT scores was also obtained. Spearman correlation analysis was performed to evaluate the correlation between CT scores and SNOT-22 scores. Forty-four non-eosinophilic CRSwNP(neCRSwNP) and 93 eosinophilic CRSwNP (eCRSwNP) patients were recruited. There was significant association between LM total score and nasal subdomain of SNOT-22 in the overall CRSwNP patients. The nasal symptom of SNOT-22 was significantly associated with maxillary, frontal, sphenoid, anterior drainage, and posterior drainage in all CRSwNP patients. In eCRSwNP and neCRSwNP patients, the sense of smell/taste was associated with sphenoid and posterior drainage. Thick nasal discharge was positively correlated with maxillary, frontal, and anterior drainage only in eCRSwNP patients. The high score of sphenoid and posterior drainage may suggest the occurrence of loss of sense of smell/taste, while high score of maxillary sinus may indicate suffering from thick nasal discharge in eCRSwNP patients.
Pubmed PDF WebKimitaka Kaga Makiko Kaga Mitsuko Shindo a National Institute of Sensory Organs, NHO Tokyo Medical Center, Tokyo, Japanb Department of Child Neurology, Tokyo Metropolitan Tobu Medical Center, Tokyo, Japanc National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japand Department of Social Welfare, Showa Women’s University, Tokyo, Japan
Publicatie 29-11-2024
There are two types of central auditory disorders due to pathology of the bilateral auditory cortices in adult patients: The aim of this case report was to illustrate the pathophysiology of auditory changes in a 1 year-3 months old child who was diagnosed with auditory agnosia as a sequel of herpes encephalitis and later developed cortical deafness during a 36-year follow-up. Brain MRI, hearing tests, ABR, DPOAE and developmental tests of speech/language were periodically performed. Brain imaging revealed extensive damage in the bilateral auditory cortices. His auditory speech perception was lost and his language development was seriously delayed. His hearing threshold progressively decreased over time from normal at first to profound hearing loss as a teenager. However, at 29 years of age his ABR was normal. He was able to communicate and converse by sign language or writing. Later developing cortical deafness with profound hearing loss could be caused by retrograde degeneration of the auditory radiation overtime to the bilateral medial geniculate bodies.
Pubmed PDF WebSeiya Goto Hidenori Suzuki Shintaro Beppu Daisuke Nishikawa Michi Sawabe Hoshino Terada Nobuhiro Hanai Michihiko Sone a Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japanb Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japanc Division of Head and Neck Surgery, Shizuoka Cancer Center, Shizuoka, Japan
Publicatie 29-11-2024
Prognostic factors from neck dissection for regional recurrent or residual head and neck cancer remain undetermined. We studied whether continuous variables from pathologic lymph nodes of salvage neck dissection could estimate survival outcomes in patients with head and neck squamous cell carcinomas (HNSCC). Pathologic continuous variables from neck dissection without primary tumor resection in 184 patients with HNSCC were retrospectively evaluated. Cutoff values from both lymph node density (LND) and log odds of positive lymph nodes (LODDS) as the variables were applied to death estimation. Uni-/multivariate survival analyses adjusting for pathologic N classification and extranodal extension were evaluated by log-rank test or Cox's proportional hazard model, respectively. LND ≥ 0.14 and LODDS ≥ -1.72 were significantly related to univariate shorter survival outcomes. Multivariate analysis indicated a significant association between LND ≥ 0.14 and shorter overall (hazard ratio [HR] = 2.16, 95% confidence interval [CI] = 1.30-3.58), local recurrence-free (HR = 2.34, 95% CI = 1.06-5.16), regional recurrence-free (HR = 2.32, 95% CI = 1.27-4.25), and distant metastasis-free survival (HR = 2.17, 95% CI = 1.31-3.61). Based on the obtained results, increased LND was a poor prognostic factor following salvage neck dissection.
Pubmed PDF WebTakashi Kasai Akira Sasaki Shuya Kasai Shiori Miura Shinichi Goto Ryoko Yotsuyanagi Tatsuya Mikami Yoshinori Tamada Ken Itoh Atsushi Matsubara a Department of Otorhinolaryngology, Hirosaki University Graduate School of Medicine, Hirosaki, Japanb Department of Stress Response Science, Biomedical Research Ceonter, Hirosaki University Graduate School of Medicine, Hirosaki, Japanc Innovation Center for Health Promotion, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
Publicatie 06-12-2024
Single-nucleotide polymorphisms (SNPs) of the This study aimed to evaluate the effect of This study included participants from the Iwaki Health Promotion Project. The genotypes of Among the 306 CC+CA and 31 AA group male subjects, 22 (7.2%) and six (19.4%), respectively, had hearing loss, with a significant difference. Multiple logistic regression analysis showed that the risk of hearing loss in the male subjects was significantly higher in the AA group than that in the CC+CA group ( The genotypes of
Pubmed PDF WebPaul Zhaobo Liu Dimitrios Spinos Amr Allam Patrick Long Wai Sum Cho Neil Fergie a ENT Department, Queen’s Medical Centre, Nottingham, UKb ENT Department, Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, UKc General Surgery Department, Tauranga Hospital, Tauranga, New Zealand
Publicatie 09-12-2024
Recurrence rate of necrotising otitis externa (NOE) after treatment is 15-20%. This is mainly due to a lack of reliable clinical indicator for the resolution of disease. We aim to assess the predictability of the otalgia, otorrhoea and C-reactive protein (CRP) levels in a large cohort of sixty-two patients for treatment outcome. Consecutive patients treated for NOE in our Nottingham tertiary ENT referral unit were retrospectively reviewed from January 2017 to June 2020. Diagnoses were made based on clinical findings and imaging. Good response to treatment was defined as those who required treatment of not longer than the standard six weeks of systemic antibiotics. Average age at presentation was 78.4 years. 75.8% of patients were male. 62.9% had diabetes. Ten patients received more than the standard six weeks of systemic antibiotics. Complications from disease progression included cranial nerve neuropathies (14.5%), meningitis (3.2%), and sigmoid sinus thrombosis (3.2%). Two patients had recurrent or persistent NOE and died while on treatment. Delays in normalization of CRP ( Normalisation of CRP and resolution of otorrhea can assist in identifying patients who will likely benefit from a prolonged course of systemic antibiotics.
Pubmed PDF WebNishan Chen Tongxiang Diao Jilei Zhang Lisheng Yu Department of Otorhinolaryngology, Head and Neck Surgery, People’s Hospital, Peking University, Beijing, PR China
Publicatie 12-12-2024
Due to the therapeutic needs of inner ear diseases, a simple method of inner ear drug delivery has been under exploration. Postauricular administration, which involves injecting the drug through the middle of the retroauricular groove, is a potential novel approach, but its mechanisms remain unclear. To investigate threshold shifts in the auditory brainstem response (ABR), as well as the morphology and quantity of hair cells on the bilateral inner ear of guinea pigs after postauricular neomycin administration. Thirty healthy guinea pigs were divided randomly into two groups and administered either neomycin 200 mg/kg or saline 1 ml The ABR results showed that at a frequency of 16 kHz, the threshold shift was 21.00 ± 14.49 dB in the neomycin injection side, 10.00 ± 16.67 dB in the contralateral side, and 0.50 ± 3.69 dB in the saline group. At a frequency of 24 kHz, the threshold shift was 37.00 ± 16.36 dB in the neomycin injection side, 14.50 ± 9.26 dB in the contralateral side, and 1.00 ± 2.11 dB in the saline group. Histopathological analysis revealed that the outer hair cells (OHCs) in the neomycin injection side suffered significant morphological and numerical loss, while the OHC loss in the contralateral ear was less severe than in the injection side but greater than in the saline group. This study confirms that postauricular administration is a novel method of local drug delivery to the inner ear, which has practical value in future experimental modeling and the treatment of inner ear diseases.
Pubmed PDF WebYunyi Lu Yutong Wu Dong Zeng Chi Chen Panpan Bian Baicheng Xu Department of Otorhinolaryngology, Lanzhou University Second Hospital, Lanzhou, China
Publicatie 13-12-2024
Cochlear implants (CI) help regain perception of sound for patients with sensorineural hearing loss. The ability to recognize music pitch may be crucial for recognizing and producing speech for Mandarin. This study aims to search for possible influencing factors of music perception and correlations between music perception and auditory speech abilities among prelingually deaf pediatric Mandarin-speaking CI users. Music perception of 24 pediatric CI users and 12 normal hearing children was measured using the MuSIC test. Auditory speech perception of the 24 CI users was also measured and analyzed with their music perception results. Pediatric CI users performed worse than normal hearing children in pitch, rhythm and melody discrimination tests ( Prelingually deaf pediatric CI users who received implantation before the age of five perform better in music perception tests. Pediatric CI users with better music perception show better auditory speech perception of Mandarin.
Pubmed PDF WebHye Ah Joo Kanggil Park Jun-Sik Kim Young Hyun Yun Dong Kyu Lee Seung Cheol Ha Namkug Kim Jong Woo Chung a Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Koreab Department of Biomedical Engineering, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Koreac University of Ulsan College of Medicine, Seoul, Korea
Publicatie 06-12-2024
Optimizing the educational experience of trainees in the operating room is important; however, ear anatomy and otologic surgery are challenging for trainees to grasp. Viewing otologic surgeries often involves limitations related to video quality, such as visual disturbances and instability. We aimed to (1) improve the quality of surgical videos (tympanomastoidectomy [TM]) by using artificial intelligence (AI) techniques and (2) evaluate the effectiveness of processed videos through a questionnaire-based assessment from trainees. We conducted prospective study using video inpainting and stabilization techniques processed by AI. In each study set, we enrolled 21 trainees and asked them to watch processed videos and complete a questionnaire. Surgical videos with the video inpainting technique using the implicit neural representation (INR) model were found to be the most helpful for medical students (0.79 ± 0.58) in identifying bleeding focus. Videos with the stabilization technique Surgical videos using video inpainting and stabilization techniques with AI were beneficial for educating trainees, especially participants with less anatomical knowledge and surgical experience.
Pubmed PDF WebLevent Şimşek M. Selman Yıldırım Çağatay Han Ülkü Ayşe Gül Zamani a Department of Medical Genetics, Necmettin Erbakan University Meram Medical Faculty, Konya, Turkeyb Department of Medical Genetics, Sancaktepe Şehit Prof. Dr. İlhan Varank, Training and Research Hospital, İstanbul, Turkeyc Department of Otorhinolaryngology, Necmettin Erbakan University Meram Medical Faculty, Konya, Turkeyd Department of Otorhinolaryngology, Istanbul Medipol University Faculty of Medicine, İstanbul, Turkey
Publicatie 09-12-2024
Cholesteatoma is a proliferative disease that affects the tympanic cavity and temporal bone. Despite many studies and various theories, the etiopathogenesis of cholesteatoma has not been fully elucidated. Features such as invasion, migration, uncontrolled proliferation, and lack of differentiation are observed in both cholesteatoma and neoplasia. The aim of this study is to investigate somatic genetic alterations in known proto-oncogenes and tumor suppressor genes in cholesteatoma. 60 different known proto-oncogenes and tumor suppressor genes were comparatively analyzed in cholesteatoma and peripheric blood samples from 15 middle ear cholesteatoma patients using next-generation sequencing. JAK3 c.2164G > A, TP53 c.284delC, and KRAS c.377A > T alterations were observed in cholesteatoma tissue but not in normal tissue. In addition, 12 different germline variants were also identified in 8 patients. In this study, the presence of changes in cancer-related genes in cholesteatoma was determined and these changes were discussed in terms of possible clinical applications. We hope that the genetic alterations that emerged in this study, will be beneficial in guiding future research in this field.
Pubmed PDF WebIda-Marie Jacobsen Amanda-Louise Fenger Carlander Mathilde Aakilde Christian von Buchwald Department of Otorhinolaryngology, Head and Neck Surgery, and Audiology, Rigshospitalet, Copenhagen, Capital Region, Denmark
Publicatie 29-11-2024
Infection with human papillomavirus (HPV) low-risk type 6 and 11 in the respiratory tract can cause recurrent benign squamous papillomas in the larynx, in children, juvenile-onset recurrent respiratory papillomatosis (JoRRP). This systematic review investigated the impact of national HPV vaccination programs on JoRRP incidence and prevalence. PubMED was systematically searched for publications between 2010 and March 2024 that assessed the incidence and prevalence of JoRRP post-implementation of HPV vaccination programs. Four studies met the inclusion criteria, comprising 622 patients with JoRRP (range 15-576) from Australia, New Zealand and the Unites States. The majority were girls (F:M ratio 2:1), with a median debut age between three to four years. Two studies ( Our findings indicate implementation of HPV-vaccination programs reduced the JoRRP incidence and prevalence emphasizing the importance of large-scale HPV vaccination. Total impact of HPV vaccination will become fully evident when the vaccinated population reach childbearing ages.
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